Is the first comprehensive review of the Zic family-related studies in biology and medicine
Presents the Zic genes for the nervous system appearance is utilized in the animal evolution

Provides the cutting edge information for common genetic disorders, stem cell and cancer cell biology

Autorentext

Jun Aruga is a professor of pharmacology at Nagasaki University Institute of Biomedical Sciences, and a former head of the Laboratory for Behavioral and Developmental Disorder at RIKEN Brain Science Institute. He has been researching the biological significance of ZIC family genes since their discovery in 1991.

Inhalt
Part1: Zic family in animal evolution and development. Comparative genome analysis of Zic genes.- Drosophila Zic genes.- Nematode Zic genes.- Planarian Zic genes.- Ascidian (Halocynthia) Zic genes.- Ascidian (Ciona) Zic genes.- Amphibian Zic genes.- Teleost fish (Oryzias) Zic genes.- Teleost fish (Danio) Zic genes.- Overview of rodent Zic genes.- Rodent Zic genes in neural network wiring.- Rodent Zic genes in meninx and vasculature development.- Part2ZIC family in Medicine: ZIC family as the causative genes for developmental disorders. ZIC1 in Dandy-Walker malformation.- ZIC2 in holoprosencephaly Maximilian.- Ch.16 ZIC3 in heterotaxy.- Part3ZIC family in Medicine: ZIC family in stem cell biology. Role of Zic family in transcriptional regulation and chromatin remodeling.- Deregulation of ZIC family in oncogenesis.- ZIC family and stemness.- ZIC2 in cancer stem cell.