Klappentext

Women and Health, Third Edition, Volume Two provides a comprehensive overview of health issues affecting women at various stages of life, from adolescence to old age. Unlike other books that focus solely on reproductive health, this volume covers a broad spectrum of topics including osteoporosis, breast cancer, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease, chronic illnesses, substance abuse, and the impact of societal and behavioral factors on health. Its international perspective ensures a holistic approach to understanding women's health.

In this new edition, the book emphasizes the health of mid-life and older women, incorporating the latest scientific findings and controversies. It delves into genetics and the influence of sex and gender on health, offering valuable insights for lay readers, clinicians, and health research scientists. This edition captures the maturity of the field of women's health since previous editions, presenting an updated compendium of the epidemiology of health conditions affecting women throughout their lives.

Inhalt

Section A Metalloenzymes

1. Introduction to metalloenzymes: From bench to bedside

   Section B Magnesium and calcium-containing enzymes
   2.1 DNA and RNA polymerases
   2.2 Reverse transcriptase
   2.3 Integrase
   2.4 Cyclin-dependent kinase 2 (CDK2)
   2.5 Catechol-O-methyltransferase (COMT)
   2.6 D-Alanine-D-alanine ligase
   2.7 Paraoxonases
   2.8 Phospholipases A2

   Section C Zinc enzymes
   3.1 Carbonic anhydrases
   3.2 Metallo-ß-lactamases
   3.3 Bacterial zinc proteases
   3.4 Matrix metalloproteases
   3.5 A disintegrin and metalloproteinases (ADAMs) and tumor necrosis factor-alphaconverting enzyme (TACE)
   3.6 Angiotensin-converting enzyme
   3.7 Histidinol dehydrogenase
   3.8 Histone deacetylases and other epigenetic targets
   3.9 CD73 (5'-Ectonucleotidase)
   3.10 Glyoxalase II
   3.11 Glutamate carboxypeptidase II
   3.12 Neutral endopeptidase (neprilysin)

   Section D Other metalloenzymes
   4.1 The role of arginase in human health and disease
   4.2 Methionine aminopeptidases
   4.3 1-Deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme in the MEP terpenoid biosynthetic pathway- Its chemical mechanism and inhibition

   Section E Nickel enzymes
   5.1 Urease
   5.2 Methyl-coenzyme M reductase

   Section F Iron enzymes (heme-containing)
   6.1 Cyclooxygenase
   6.2 Cytochrome P450 (inhibitors for the metabolism of drugs)
   6.3 Aromatase

   Section G Iron enzymes, non-heme containing
   7.1 Nonheme mono- and dioxygenases
   7.2 Indoleamine 2,3-dioxygenase

   Section H Copper enzymes
   8.1 Superoxide dismutases inhibitors
   8.2 Tyrosinase enzyme and its inhibitors: An update of the literature

   Section I Cadmium enzymes CAs

2. CDCA1, a versatile member of the -class of carbonic anhydrase family

   Section J Molybdenum enzymes

3. Molybdenum enzymes

   Section K Tungsten-containing enzymes

4. Tungsten-containing enzymes