This book emphasizes the atom economy aspect of multicomponent reactions. It describes how this methodology has been applied to several named reactions. Among the twelve principles of green chemistry, atom economy addresses 'synthetic efficiency'. A multicomponent reaction can be defined as an energy, cost, and time efficient method for organic synthesis. Instead of making one or two bonds in a chemical transformation, multicomponent reactions generate several chemical bonds in a single operation. This book presents a series of detailed reaction mechanisms that beautifully illustrate this principle. Multicomponent reactions are widely applied to the preparation of complex and diverse molecular structures in academic and industrial research laboratories. As such, this book is targeted at researchers involved in green organic chemistry.

Includes reaction mechanisms Exclusively features multicomponent reactions Focuses on the green chemistry aspects of multicomponent reactions

Autorentext

Dr. Wei Zhang is a Professor and the Director of the Center for Green Chemistry at the University of Massachusetts Boston. He received his PhD and did his post-doctoral research at the University of Pittsburgh. His previous positions include Research Assistant Professor at the University of Pittsburgh, Senior Chemist at DuPont, and Director at Fluorous Technologies, Inc. Prof. Zhang's research is in the areas of fluorous chemistry, organocatalysis, medicinal chemistry, and green chemistry. He has coauthored over 250 papers including three in Chem. Rev., co-edited "Green techniques for organic and medicinal applications" (Wiley 2012 & 2018), and a SpringerBrief "Pot, Atom, and Step Economy (PASE) Synthesis" (2019). He is editor and editorial advisory member of nine international journals. Dr. Wenbin Yi studied chemistry at Nanjing University of Science & Technology (NJUST) and received B.Sc. (2002) and Ph.D. (2006) under the supervision of Professor Dr Chun Cai. He is currently a Professor in Department of Pharmaceutical and Fine Chemicals at NJUST. His research interests focus on fluorine chemistry with an emphasis on green synthetic methods. He has published over 100 scientific papers in the journals such as Angew. Chem. Int. Ed., J. Am. Chem.Soc, Nat. Commun., CCS Chemistry, and Green Chem. Dr. Xiao Gao studied material chemistry at Doshisha University and received B.Sc. After that, he finished his Master course at Osaka University. At 2020, he finished his Ph.D. at Kyoto University under the supervision of Professor Dr Yoshiharu Uchimoto. He is currently an assistant professor in the Department of Pharmaceutical and Fine Chemicals at NJUST. His research interests focus on green chemistry, renewable energy, polymer electrolyte, electrochemical interface. He has published over 10 scientific papers in journals such as Langmuir, ACS omega, and ACS Appl. Eng. Mat.

Inhalt
Multicomponent reaction.- Introduction.- The Ugi reaction.- The passerini reaction.- The Strecker reaction.- The Hantzsch reaction.- The Biginelli raction.- Other Style reaction.- One-pot synthesis.- Introduction.- Various Catalyst.- Cascade reactions.- Introduction.- Application.- Classification.