Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient ordeficient vitamin D levels for multiple reasons.

This book will focus on vitamin D in Chronic Kidney Disease states Discusses recent insights on vitamin D metabolism as well as its association with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction New players in the regulation of vitamin synthesis and degradation have been identified and largely explored in case of CKD including FGF23 and klotho

Autorentext

Pablo URENA TORRES, M.D., Ph.D.
Department of Nephrology and Dialysis. Clinique du Landy. 23, rue du Landy. 93400 Saint Ouen, France, and Department of Department of Renal Physiology. Necker Hospital, University of Paris Descartes, Paris, France

Mario COZZOLINO, M.D. Ph.D.
Department of Health Sciences, Renal Division, San Paolo Hospital, University of Milan, Milan, Italy

Marc G. VERVLOET, M.D., Ph.D.
Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

Klappentext

This book provides the entire physiology, pathology, and clinical and therapeutical aspects of vitamin D in the setting of Chronic Kidney Disease (CKD). The chapters, divided into major sections, delve into the metabolism of vitamin D, its assessment methods, and the worldwide epidemiology of vitamin D deficiency. The authors also address the classical biological and biochemical effects vitamin D has on mineral and bone metabolism, as well as on a variety of other non-classic target organs, and look at the effects of vitamin D treatment in CKD.

Vitamin D in Chronic Kidney Disease is an extremely timely book that collects the most recent biological, clinical and therapeutic insights, to greatly impact the nephrology community as well as other connected medical specialties.

Inhalt
Section I. Generalities, Measurement and Epidemiology Chapter 1. Vitamin D Metabolism in Normal and Chronic Kidney Disease States Chapter 2. Epidemiology of Vitamin D Deficiency in Chronic Kidney Disease Chapter 3. Molecular Biology of Vitamin D: Genomic and Nongenomic Actions of Vitamin D in Chronic Kidney Disease Chapter 4. Vitamin D Receptor and Interaction with DNA: From Physiology to Chronic Kidney Disease Chapter 5. Measurement of Circulating 1,25-dihydroxyvitamin D and Vitamin DBinding Protein in Chronic Kidney Diseases SECTION II. Classical Mineral and Bone Effects Chapter 6. Vitamin D and Racial Differences in Chronic Kidney Disease Chapter 7. Vitamin D and Parathyroid Hormone Regulation in Chronic Kidney Disease Chapter 8. The Parathyroid Type I Receptor and Vitamin D in Chronic Kidney Disease Chapter 9. Vitamin D and Klotho in Chronic Kidney Disease Chapter 10. Vitamin D and FGF23 in Chronic Kidney Disease Chapter 11. Wnt/sclerostin and the Relation with Vitamin D in Chronic Kidney Disease Chapter 12. Vitamin D and Bone in Chronic Kidney Disease Chapter 13. Vitamin D in Children with Chronic Kidney Disease: A Focus on Longitudinal Bone Growth SECTION III. Non-classical Effects of Vitamin D Chapter 14. Vitamin D and Progression of Renal Failure Chapter 15. Vitamin D and Diabetes in Chronic Kidney Disease Chapter 16. Vitamin D and Muscle in Chronic Kidney Disease Chapter 17. Vitamin D Deficiency and Infection in Chronic Kidney Disease Chapter 18. Vitamin D and Inflammation in Chronic Kidney Disease Chapter 19. Vitamin D and Heart Structure and Function in Chronic Kidney Disease Chapter 20. Vitamin D and Endothelial Function in Chronic Kidney Disease Chapter 21. Vitamin D and Cardiovascular Calcification in Chronic Kidney Disease< Chapter 22. Calciphylaxis and Vitamin D Chapter 23. Vitamin D and Anemia in Chronic Kidney Disease Chapter 24. Vitamin D and Mortality Risk in Chronic Kidney Disease SECTION IV: Kidney Transplantation Chapter 25. Vitamin D in Kidney Transplantation Chapter 26. Vitamin D in Acute and Chronic Rejection of Transplanted Kidney Chapter 27. Nutrition and Dietary Vitamin D in Chronic Kidney Disease Chapter 28. Natural Vitamin D in Chronic Kidney Disease Chapter 29. Which Vitamin D in Chronic Kidney Disease: Nutritional or Active Vitamin D? Or both? Chapter 30. Use of New Vitamin D Analogs in Chronic Kidney Disease Chapter 31. Interaction Between Vitamin D and Calcimimetics in Chronic Kidney Disease