"Who would believe that so small a space could contain the images of all the universe?" Leonardo da Vinci The last years of the 20th century have found the discipline of Developmental Biology returning to its original position at the forefront of biological re search. This progress can be attributed to the burgeoning knowledge base on molecules and gene families, and to the power of the molecular genetic ap proach. Topping the list of organ systems which have provided the most significant advances would have to be the eye. The vertebrate eye was one of the classic embryologic models, used to demonstrate many important prin ciples, including the concepts of inductive tissue interactions first put forth in the early 1900s. Within the last decade of this century, a return to some of the old questions with the new approaches has put eye development back into the limelight. I find this a highly appropriate topic for a book which aims to spark research for the new millennium. We begin with a chapter that discusses the anatomy of eye development, providing the basic reference information for the chapters that follow. A novel aspect of this introduction is the connection made between develop mental strategies and the eye's optical function. What also emerges from this chapter is the number of important eye structures that have barely been touched by the modern developmental biologist. Work on cornea and ante rior chamber development has lagged behind lens and retina.

This book gives a comprehensive overview of the development and molecular biology of the vertebrate eye. Includes supplementary material: sn.pub/extras

Inhalt
Overview.- Vertebrate Eye Development and Refractive Function: An Overview.- Early Pattern Formation.- Pax6 and the Genetic Control of Early Eye Development.- Early Retinal Development in Drosophila.- Embryonic Induction.- Induction of the Lens.- Retinal Differentiation.- Molecular Control of Cell Diversification in the Vertebrate Retina.- Cell Fate Specification in the Drosophila Retina.- Roles of the Extracellular Matrix in Retinal Development and Maintenance.- Adhesive Events in Retinal Development and Function: The Role of Integrin Receptors.- Formation of Neural Pathways for Vision.- Connecting the Eye with the Brain: The Formation of the Retinotectal Pathway.- Regeneration.- Regeneration of the Lens in Amphibians.- How the Neural Retina Regenerates.- Genetic Models.- Mouse Mutants for Eye Development.- Genetic Analysis of Eye Development in Zebrafish.