The second edition of the book published by Springer in 2006, Optical Polarization in Biomedical Applications concerns the optical methods exploring a unique feature of light its polarizationfor quantitative tissue characterization. The new edition will introduce new topics and expand on existing, cutting-edge developments in this field. Particular attention is paid to recent theoretical and instrumental advances in Mueller polarimetry and their potential clinical applications, a discussion of the principles and concepts of optical tissue clearing, orbital angular momentum, and quantum entangled photons in tissue polarization optics, polarization encoding and symbolic mapping of DNA sequences, and machine learning for pathology signature extraction.

Some polarization-sensitive optical methods have already found clinical application, while others are still in the research phase but could become breakthrough technologies in various medical fields in the near future. Recent developments in Stokes-Muller polarimetry have led to extensive ex vivo and in vivo studies of various tissues. Important advances have been made in the field of matrix Mueller algebra for post-processing of diagnostic data, in the extension of the polarization Monte Carlo method to the study of scattering anisotropic media for the purpose of simulating the interaction of polarized light with tissue, and in the search for optimal optical markers for certain types of pathologies. These results are of interest to optical engineers, researchers, students, and clinicians seeking new, revolutionary approaches to solving diagnostic problems by assessing the presence of microstructural features to determine tissue integrity and in the development of new polarimetric technologies.

Presents the current state of the art in visible light-based biomedical imaging Includes polarimetric properties of biological tissues Discusses clinical applications of polarized light techniques

Autorentext

Valery V. Tuchin is the Head of the Department of Optics and Biophotonics and the Science Medical Center of Saratov State University, the Laboratory of Biophotonics of Tomsk State University and the Laboratory of Laser Diagnostics of Technical and Living Systems of the Institute of Precision Mechanics and Control of the Federal Research Center "Saratov Scientific Center of the Russian Academy of Sciences," Russia. His research interests include tissue optics, tissue optical clearing, laser medicine and nanobiophotonics. Professor Tuchin is a Corresponding Member of the Russian Academy of Sciences, a Fellow of SPIE and OSA/OPTICA. He is an Honored Scientist of the Russian Federation, FiDiPro (Finland), a laureate of the SPIE Educator Award, the J.W. Goodman Book Writing Award, the M.S. Feld Prize in Biophotonics, and the Chime Bell Award of the Chinese province of Hubei. He has the title of "Professor of the Year" in Russia, the title of "Scientist of the Year" of the "Vyzov" Foundation, and has been awarded the D.S. Rozhdestvensky, S.I. Vavilov and A.M. Prokhorov medals and has many other awards. He is the founder, editor-in-chief and member of the editorial board of many journals in the field of biomedical optics, biophotonics and biomedical engineering, and the founder and chair of several world-renowned international conferences. He has published more than 40 books and 1000 papers, which have been cited more than 46,300 times. Tatiana Novikova received her M.S. degree (Cum Laude) in Applied Mathematics from Moscow State University, Russia, a Ph.D. in Applied Physics and Mathematics from Moscow Institute of Mathematical Modeling, Russian Academy of Sciences, and an HDR (Dr. habil.) in Physics from Paris-Sud University, Orsay, France. She leads the Characterization and Modeling Division of the Laboratory of Interfaces and Thin Films at Ecole polytechnique, IP Paris, France, and also serves as a Courtesy Professor in the Department of Biomedical Engineering at Florida International University, Miami, USA. Her research interests and expertise include optical polarization, Mueller polarimetry, biomedical imaging, clinical applications of polarized light, optical metrology, and computational modeling of electromagnetic wave interaction with structured and random media. Dr Novikova is an editorial board member of the SPIE Journal of Biomedical Optics, Vice-Chair of the Poincaré Webinar Series "Optical Polarization and Related Phenomena", the co-founder and chair of both SPIE Photonics West BiOS symposium "Polarized light and Optical Angular Momentum for biomedical diagnostics" and International Workshop "Biophotonics and Optical Angular Momentum". Dr. Novikova is a Fellow of SPIE and OPTICA/OSA and a recipient of the 2020 SPIE G.G. Stokes Award in Optical Polarization. Lihong Wang edited the first book on photoacoustic tomography. His book entitled "Biomedical Optics: Principles and Imaging," one of the first textbooks in the field, won the 2010 Joseph W. Goodman Book Writing Award. He has published 615 peer-reviewed journal articles and delivered 630 keynote/plenary/invited talks. His Google Scholar h-index and citations have reached 166 and 118,000, #1 most cited in optics according to Stanford/Elsevier. His laboratory was the first to report functional photoacoustic tomography, 3D photoacoustic microscopy, photoacoustic endoscopy, photoacoustic reporter gene imaging, the universal photoacoustic reconstruction algorithm, and CUP (world’s fastest camera). He chairs the annual conference on Photons plus Ultrasound, the largest conference at Photonics West. He was the Editor-in-Chief of the Journal of Biomedical Optics. He received the NIH Director’s Pioneer, NIH Director’s Transformative Research, and NIH/NCI Outstanding Investigator awards. He also received the OSA C.E.K. Mees Medal, IEEE Technical Achievemen

Inhalt

.- Introduction.

.- Tissue Structure and Optical Models.

.- Polarized Light Interactions with Weakly Scattering Media.

.- Polarized Light Interactions with Strongly Scattering Media.

.- Polarization Properties of Tissues and Phantoms.

.- Polarization-Dependent Interference of Multiply Scattered Light.

.- Decay of Light Polarization in Random Multiple Scattering Media.

.- Degree of Polarization in Laser Speckles from Turbid Media.

.- Monte Carlo Modeling of Polarization Propagation in Strongly Scattering Media.

.- Polarization-Sensitive Optical Coherence Tomography.

.- Biomedical Diagnostics and Imaging.

.- Tissue Optical Clearing.

.- Mueller Polarimetry of Tissue.

.- Polarization-Based Mapping and Analysis of Nucleotide Sequences in Bioinformatics: Basic Principles and Prospects.

.- Orbital Angular Momentum and Quantum Entangled Photons in Tissue Optics.