This book presents a new diagnostic approach that utilizes complex statistical, correlation, fractal, and singular analysis of spatial distribution of the Stokes vector of scattered polarized light in different diffraction zones. The technique is able to identify changes in the distribution of optical axes and the birefringent indices of multi-layered fibrillar networks of biological tissues. The book also presents various scenarios for the formation of polarization singularities in laser speckle images of phase-inhomogeneous, multi-layered biological tissues in terms of the characteristic values of Mueller-matrix images. Moreover, in the context of potential diagnostic applications, it discusses the states of polarization singularities and their changes associated with the pathological abnormalities of the extracellular matrix of human tissues, its spatial peculiarities and structural orientation.

Autorentext

Bachinskyi Victor was born in 1952. In 1976, he graduated from Chernivtsi State Medical Institute and received Candidate of Medical Sciences in 1988. He was awarded the Title of Associate Professor of the Department of Pathology and Forensic Medicine in Bukovinian State Medical University in 1991. Doctor of Medical Sciences from 2009, the topic of his dissertation was: "Laser spectroscopy of biological tissues to develop objective criteria forensic determination of death and old time hematoma formation." He was awarded the Title of Professor of the Department of Pathology and Forensic Medicine in 2011.
Vanchulyak Oleg was born in 1976. Candidate of Medical Sciences, in 2007, he defended his book on "Diagnosis of death prescription by laser polarimetric monitoring of human tissue." MD, in 2017, he defended his doctoral book on "Peer review of acute myocardial ischemia polarization-correlation method." In 2009, he was awarded the highest category of medical specialty "Forensic examination" and transferred to the post of Associate Professor Bukovina State Medical University. In 2011, he received the rank of Associate Professor. From September 2018, he is the Professor of the Department of Forensic Medicine. A. G. Ushenko, Ph.D., D.Sc., is a Professor and a Head of the Department of Optics and Spectroscopy at the Chernivtsi National University (Ukraine). He is the author and co-author of over 150 papers in peer-reviewed scientific journals and proceedings of international conferences, 14 books, and 37 patents. His area of expertise includes polarimetry of biological tissues and fluids and autofluorescence polarimetry. Yu. A. Ushenko, Ph.D., D.Sc., is an Associate Professor at the Department of Correlation Optics at the Chernivtsi National University (Ukraine). He is the author and co-author of over 120 papers in peer-reviewed scientific journals and proceedings of international conferences, 5 books, and 16 patents. His area of expertise includes multivariate polarization and autofluorescence microscopy of biological tissues and fluids. Alexander Dubolazov is an Associate Professor at the Chernivtsi National University. He received his B.S. and M.S. degrees in optics from the Chernivtsi National University in 2006 and 2007, respectively, and his Ph.D. degree in optics, laser physics from the Chernivtsi National University in 2010. He is the author of more than 100 journal papers and has written five book chapters. His current research interests include laser polarimetry, holography, etc.
Igor Meglinski, M.Sc., Ph.D., is a Professor of Aston University (UK) and University of Oulu (Finland). His research interests lie at the interface between physics, optical, and biomedical engineering, sensor technologies, and life sciences, focusing on the development of new non-invasive imaging/diagnostic techniques and their application in medicine & biology, material sciences, pharmacy, food, environmental monitoring, and healthcare industries. Professor Meglinski is the author and co-author of over 230 papers in peer-reviewed scientific journals, proceedings of international conferences, books, book chapters, patents, and professional magazines. He is Chartered Physicist (CPhys), Chartered Engineer (CEng), the Node Leader in Biophotonics4Life Worldwide Consortium (BP4L), Fellow of the Institute of Physics (UK), and Fellow of SPIE.

Inhalt
Introduction.- Materials and Methods.- Results and discussion.- Conclusions.