This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.

Outlines the state-of-the-art in hydrogel tunability Discusses the smart material design of natural and synthetic hydrogels Presents the latest literature on the applications of tunable hydrogels in in vitro assays and tissue engineering

Autorentext

Dr. Antonina Lavrentieva is a group leader at the Institute of Technical Chemistry, Leibniz University of Hannover, working in the field of stem cell research, biotesting and tissue engineering. In her second Ph.D. thesis, she studied methods of expanding mesenchymal stem cells (MSCs) in bioreactors, as well as the influence of hypoxia on the MSCs. She studied Biology and Life Science at Moscow State University and the University of Hannover, and she also defended a Ph.D. thesis in Physiology. Her current research interests include stem cell media optimization, hypoxia, 3D cell culture and gradient hydrogels for studying stem cell niches and 3D-bioprinting. She is also the current head of the advisory board of DECHEMA professional group "Medical biotechnology".

Dr. Iliyana Pepelanova is a group leader at the Institute of Technical Chemistry at the Lebniz Univeristy of Hannover. She holds degrees in Chemistry (B. Eng.) and Life Science (M. Sc.), and receiveda Ph.D. in Biotechnology from the Leibniz University in 2012. Her research focuses on the synthesis of biohybrid hydrogels with tunable mechanical properties for 3D cell culture and biomedical applications. Her group also investigates the production of protein-based hydrogels from the extracellular matrix in simple microorganisms using recombinant technology. Additional areas of research include the production of bioactive nanopills and the production of recombinant cytokines in animal-component free processes for easier regulatory certification.

Prof. Dr. Dror Seliktar is an Associate Professor at the Technion Faculty of Biomedical Engineering. Dr. Seliktar received his B.Sc. in Mechanical Engineering from Drexel University in 1994 and his M.Sc. in Mechanical Engineering and Ph.D. in Biomedical Engineering from the Georgia Institute of Technology in 2000. His research focuses on tissue engineering and regenerative medicine, including the design and development of bio-synthetic hybrid hydrogels for tissue engineering and regeneration; the regulation of cellular morphogenesis via physical properties of the provisional extracellular matrix in three dimensional cultures; and the use of mechanical stimulation for optimizing the development of tissue engineered constructs.

Inhalt
Tunable Hydrogels: Introduction to the World of Smart Materials for Biomedical Applications.- Alginate Hydrogels with Tuneable Properties.- Tunable Protein Hydrogels: Present State and Emerging Development.- Nanogels Capable of Triggered Release.- Aptamer-Modified Hydrogels.- Self-Assembly and Genetically Engineered Hydrogels.- Synthetic Biology-Empowered Hydrogels for Medical Diagnostics.- Gradient Hydrogels.

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