Tumor Microenvironment

This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Reninangiotensin system, and more.

Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Provides a comprehensive overview of the state-of-the-art research on various molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Reninangiotensin system, and more Illustrates in detail how cancer cells are affected by different molecules, such as exosomes, stem cell secreted factors, and therapeutic monoclonal antibodies Describes how molecular components of the tumor microenvironment and cancer progression are intimately linked

Autorentext
Alexander Birbrair received his Bachelor's Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette's laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Inhalt

MicroRNAs in the tumor microenvironment.- The Impact of Estrogen in the Tumor Microenvironment.- The non-bone related role of RANK/RANKL signaling in cancer.- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment.- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma.- COX-2 Signaling in the Tumor Microenvironment.- Reninangiotensin system in the tumor microenvironment.- Stem cell secreted factors in the tumor microenvironment.- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy.- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms.- Index. <p