This book integrates the research progress of Tryptophan (Trp) and its metabolites in animal nutrition and human health. It recapitulates the effects of Trp nutrition on the regulation of various physiological functions in farmed animals as well as the clinical connections between Trp metabolism and human diseases. Furthermore, this book includes detailed information about the manufacturing process of industrial Trp production and methodologies to study Trp metabolism. This book not only brings numerous benefits to academic communities worldwide but also provides practical values for industrial professionals/companies. Both of these two aspects will expand our understanding of how amino acid metabolism contributes to the maintenance of host health.

This book provided a reference book for both academic communities and industries This book revealed the important physiological interactions between tryptophan metabolites and gut microbes Delineated the application of tryptophan metabolism in animal production and the potential application in human diseases

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Dr.Yulong Yin is the member of the Chinese Academy of Engineering and has been selected into the list of Highly Cited Researchers of Clarivate in 2022. Dr.Yulong Yin received his Bachelor degrees in Biology in 1978 from Hunan Normal University, Changsha, China. Then he attended Huazhong Agricultural University, Wuhan, China from 1979 to 1982 and Queens University of Belfast, Belfast, UK from 1994 to 1997, from which he obtained his Masters and Doctorate degrees in Animal Nutrition, respectively. He conducts research in animal production, animal feed, nutrition and physiology of amino acids and protein, gene expression and gene therapy, comparative animal nutrition, diabetes, obesity and cardiovascular complications, nutrition and metabolism and animal models of human diseases. Dr.Yulong Yin has made key contributions to the subject of ideal digestibility and made notable contribution to knowledge on the subject of development and standardization of ideal digestibility in pigs. He characterized virtually all the common Chinese feed ingredients used for pig feeding for their nutritive value and ileal digestibility contents. This has led to the development of up-to-date feed database used extensively in the Chinese feed industry. Apart from enhancing growth rate and profit margin in the pork industry, the development of the ileal digestibility methods and the use of ileal digestible values in feed formulation have added advantages of reducing nitrogen and phosphorus emission to the environment when used for feed formulation. In recent years, he studied the molecular mechanisms behind piglet diarrhoea and developed key technologies and a range of feed products that can reduce diarrheal incidence in piglets. Dr.Yulong Yin has played numerous leadership roles in the scientific community worldwide and has been serving on editorial boards of several prestigious journals such as Animal Nutrition, The Innovation, and Science China Life Sciences. Furthermore, Dr. Yin also received many prestigious awards and honours, among which are the prestigious German Max-planck Gesellschaft Scholarship in 1985 and 1995 and National Science and Technology Progress Prize of China in 1996, 1997 and 2008, among others. He has published a total of 777 scientific papers, which have greatly advanced the field of animal nutrition worldwide.

Dr. Sung Woo Kim is currently a WNR Distinguished Professor at North Carolina State University. Since graduation with the Ph.D. degree from the University of Illinois in 1999, Dr. Sung Woo Kim has developed a world-class and productive research program in monogastric nutrition. The results of his outstanding research have significantly advanced our knowledge about intestinal health and amino acid nutrition, and functional nutrients in monogastric animals. Together with his graduate students, visiting scholars, and collaborators, he has published over 260 peer reviewed papers, 22 book chapters, 76 papers in conference proceedings, 17 popular articles, 300 abstracts, and given over 265 invited talks in 23 countries. His publications have been extensively cited (over 21,000, h-index 76 and i10-index 201 by Mar, 2024). Dr. Kim has been servicing animal science community as Associate Editor for Journal of Animal Science, Animal Bioscience, Journal of Animal Science and Biotechnology, Animal Nutrition, Frontiers in Veterinary Science, and Toxins. His research has been supported with over 13 million US dollar grant funding and cash donations educating 24 PhD and 30 master students as the advisor, 13 PhD and 7 master students as the committee member, 44 visiting scientists, and 5 postdoctoral research associates as the supervisor. In recognition of his seminal contributions to swine nutrition, Dr. Kim has received the AFIA Award in Nonruminant Nutrition Research, Early Career Achievement Award, and Outstanding Young Scientist Award from the American Society of Animal Science; The Vernon Young International Award for Amino Acid Research from the American Society of Nutrition; and Outstanding Research Award from the Association of Asian-Australasian Animal Production. He was recognized as University Faculty Scholar by the chancellor of North Carolina State University in 2013 and William Neal Reynold Distinguished Professor in 2024.

Dr. Xiongzhuo Tang received his PhD degree in Molecular Biology at the Department of Molecular Biosciences, The Wenner-Gren Institute from Stockholm University, Sweden, in 2018. Then he completed his postdoc training in Cell Biology at Yale Stem Cell Center from Yale University, USA, from 2019 to 2022. He has made important contributions to the subject of animal *gut immunity and development. He characterized the novel function of the conserved POU transcription factor Nub in the regulation of Drosophila intestinal immune homeostasis and intestinal stem cell activities. Additionally, he conducted the pioneer research in studying the somatic function of Piwi in the maintenance of intestinal genome integrity and intestinal stem cell lineage development. These findings have been published on several prestigious journals including Stem Cell Reports, PLOS Pathogens and Genetics* et.al. Currently, Dr. Xiongzhuo Tang is a professor at the College of Animal Science and Technology at Hunan Agricultural University, Changsha, Hunan,China and his research focus is to dissect the molecular function and mechanisms of Tryptophan nutrition in animal gut health and diseases prevention.

Inhalt

Chapter 1 The origin and metabolism of Tryptophan.- Chapter 2 The function of Tryptophan metabolism in the gut.- Chapter 3 Tryptophan nutrition in swine production.- Chapter 4 Tryptophan nutrition in poultry and ruminant animals.- Chapter 5 Tryptophan metabolism in human diseases.- Chapter 6 Industrial production of tryptophan.- Chapter 7 Methodology to study Tryptophan metabolism.- Chapter 8 Conclusions and Perspectives.