These are exciting days in biology; chromosome such functional attributes of chromosomes as research is no exception. Twenty years ago when replication, dosage compensation and cellular Caspersson and coworkers showed that meta response to DNA lesions. It is only recently that a phase chromosomes are structurally not homo molecular view of the meiotic cell division is geneous through their length, a new world was beginning to emerge: chapter ten refers to human in the offing. Application of various molecular meiosis and the next to molecular events in techniques in chromosome research has subse meiotic prophase in the baker's yeast. Another quently narrowed down the gap between the chapter is on aneuploidy in man and the Djungarian levels of microscopic and molecular understand hamster. The role of chromosome rearrange ing of chromosome organization. While complex ments and oncogenes in malignancy and the ities of older questions of chromosome/ parallelism between the neoplastic and phy chromatin organization are being understood, logenetic chromosomal alterations are discussed newer dimensions and perspectives have been in the next two chapters. Recent introduction of gained with respect to their structure and func potentially useful methods of chromosome isola tions. Even more, novel chromosome techniques tion by flow cytometry, and mapping of structural have become an integral component of clinical ly and functionally distinct domains on metaphase and molecular genetic methodologies.

Klappentext

Molecular cytogenetics has developed as a vital field in clinical as well as fundamental genetics. Leading scientists contribute the most updated evidences and concepts. Starting from the DNA complexity, chromatin in interphase and metaphase, and chromosomal banding patterns, the book deals with regulation of gene expression, replication and transcription at the chromosomal level. Recent advances in the physiology of meiotic cell division, oncogenesis, dosage compensation, mechanism of aberration production and role of chromosomes in evolutionary divergence are some of the major topics covered in a single volume.

Inhalt
1 DNA Organization in the Interphase Nucleus and Metaphase Chromosome.- 2 On Interspersed Repetitive DNA Sequences in Animals.- 3 Chromatin Structure and Gene Expression in Eukaryotes.- 4 Contents of G- and R-bands Defy Contemporary Paradigms.- 5 Examination of the Structure and Function of the Mammalian Centromere.- 6 Comparative Aspects of Chromosome Replication in Drosophila and Mammals.- 7 Dosage Compensation in Drosophila and Mammals: A Review of the Past and Speculation for the Future.- 8 Steroid Sulphatase Inactivation Patterns and X-chromosome Inactivation.- 9 Chromosomal Aberrations from Radiation-induced DNA Lesions.- 10 Current and Future Trends in Human Meiotic Research.- 11 Meiotic Developmental Features Relevant to Prophase Specific Chromosomal Characteristics in Saccharomyces cerevisiae.- 12 Aneuploidy in Man and Mechanisms of Nondisjunction Inferred from Studying Djungarian Hamster Oocytes.- 13 Chromosome Alterations and Oncogenes in Human Neoplasia.- 14 Chromosome Alterations in Speciation and Neoplastic Transformation: A Parallelism.- 15 Flow-cytometry: A Tool in Cytogenetics.- 16 Restriction Enzyme Banding of Metaphase Chromosomes.- 17 DNase I-nick Translation Technique: A Cytogenetic Approach to Map Active Chromatin.- 18 Chromosomal Speciation: Constitutive Heterochromatin and Evolutionary Differentiation of the Indian Pygmy Field-Mice.- Author Index.