This volume explores the latest techniques used to study brain function and pathophysiology of major depressive disorder (MDD), and includes suggestions of new therapeutic approaches for the treatment of MDD. The chapters into this book are organized into five parts. Part One discusses advanced approaches to studying well-established pathophysiological mechanisms. Part Two details behavioral research methods for MDD. Part Three looks at the cellular and molecular research methods for major depression, and Part Four describes the latest developments in non-invasive neuroimaging. Part Five focuses on the pharmacological and non-pharmacological interactions, including antidepressant agents and their properties, such as sexual side effects and neuroimaging biomarkers. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, TranslationalResearch Methods for Major Depressive Disorders is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
The Role of Hypothalamus-Pituitary-Adrenal Axis in the Pathophysiology of Major Depression: A Translational Research Perspective of the Prednisolone Suppression Test.- The Role of Glial Pathology in Pathophysiology and Treatment of Major Depression: Clinical and Preclinical Evidence.- Neural Circuits Underlying the Pathophysiology of Major Depression.- Translational Research Approach to Neurobiology and Treatment of Major Depression: From Animal Models to Clinical Treatment.- Translational Strategies for Developing Biomarkers for Major Depression: Lessons Learned from Animal Models.- Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior.- Behavioral Paradigms for Assessing Cognitive Functions in the Chronic Social Defeat Stress Model of Depression.- Optogenetic Animal Models of Depression: From Mouse to Man.- The Effects of Antidepressants on Neurotransmission: Translational Insights from In Vivo Electrophysiological Studies.- The Role of Transcriptional Profiling in Neurobiology and Treatment of Major Depression: A Translational Perspective on RNA-Sequencing Platform.- Molecular Imaging of Major Depressive Disorder with Positron Emission Tomography: Translational Implications for Neurobiology and Treatment.- Magnetic Resonance Imaging as a Translational Research Tool for Major Depression.- Neurobiochemistry Alterations Associated with Major Depression: A Review of Translational Magnetic Resonance Spectroscopic Studies.- Deficits of Neurotransmitter Systems and Altered Brain Connectivity in Major Depression: A Translational Neuroscience Perspective.- Translational Neuropsychopharmacology for Major Depression: Targeting Neurotransmitter Systems.- Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder.- Deep Brain Stimulation for Treatment-Resistant Depression.- Serotonin Receptors and Antidepressants: Neuroimaging Findings from Preclinical and Clinical Research.- Ketamine and Other Glutamate Receptor Antagonists as Fast-Acting Antidepressants: Evidence from Translational Research.- Antidepressants, Sexual Behavior, and Translational Models for Male Sexual Dysfunction: Development of Animal Models, Pharmacology, and Genetics.