A panel of expert clinical and basic investigators summarize the state-of-the-art in the use of transgenic technology in a broad range of endocrinological applications. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology and its pathologies through mouse models, and provides a host of creative approaches to understand better the complex processes that are characteristic of hormonal systems.

Includes supplementary material: sn.pub/extras

Klappentext
Transgenic mouse technology, including embryonic stem cell and gene knockout techniques, has revolutionized the study of endocrinology by giving endocrinologists an effective set of tools for understanding endocrine physiology and pathology in vivo. In Transgenics in Endocrinology, a panel of expert clinical and basic investigators summarize the state-of-the-art in the use of this powerful technology in a broad range of endocrinological applications. These applications include studies of mammalian sexual differentiation, steroidogenesis, progesterone action in vivo, normal mammary gland development, oxytocin and vasopressin, regulation and function, skeletal biology, and prostate cancer. There are also transgenic studies of the control of ovarian function, the Bcl2 gene family, c-kit/kit ligand axis in mammalian gametogenesis, prolactin and the prolactin receptor, insulin and insulin-like growth factors, and overexpression and targeted disruption of genes involved in the control of growth, food intake, and obesity.
Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology, and its pathologies, through mouse models, and provides a host of creative approaches to better understand the complex processes characteristic of hormonal systems.

Inhalt
1 Germline Genetic Engineering Techniques in Endocrinology.- 2 The Transgenic Mouse in Studies of Mammalian Sexual Differentiation.- 3 The In Vivo Function of Müllerian-Inhibiting Substance During Mammalian Sexual Development.- 4 Control of Ovarian Function.- 5 Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression.- 6 Functional Analysis of the Bcl2 Gene Family in Transgenic Mice.- 7 The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis.- 8 Gene Knockout Approaches to Steroidogenesis.- 9 The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo.- 10 Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development.- 11 Prolactin and the Prolactin Receptor.- 12 Transgenic Models for Oxytocin and Vasopressin.- 13 Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function.- 14 Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation.- 15 Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System.- 16 Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity.- 17 Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors.- 18 Use of Transgenic Animals in Skeleton Biology.- 19 Transgenic Mouse Models of Prostate Cancer.- 20 Neural- and Endocrine-Cell-Specific Immortalization Using Transgenic Approaches.