These lectures were prepared by the authors for Seminars to be held on June 6, 1983, in St.Louis, Missouri, under the spon sorship of the Radiopharmaceutical Science Council of the So ciety of Nuclear Medicine . All manuscript? were refereed . Tracer kinetics and the modeling of physiological and bio chemical processes in vivo are the focus of a contemporary di rection in biochemical research. Recent advances in instrumen tation (especially positron emission tomography and digital autoradiography) and parallel developments in the production of short-lived radionuclides and rapid synthetic chemistry to pre pare tracers that probe metabolism, flow, receptor-ligand kinetics, etc., are responsible for new scientific frontiers. These developments, coupled with biomathematics and computer science, make it possible to quantitatively evaluate tracer kinetic models in animals and man. (The choice of animal models in radiotracer design and tracer kinetics is the subject of a book edited by R.M.Lambrecht and W.C.Eckleman in press at Sprin ger Verlag.) Tracer kinetics and physiological modeling is truly multi disciplinary, as evidenced by the intellectual diversity and international representation observable in the list of contri butors . The lectures outline and attempt to show the transition from the theoretical description to the practical application of modeling for understanding normal and pathological processes .

Inhalt
The Statistical Analysis of Pharmacokinetic Data.- Mathematical Methods in The Formulation of Pharmacokinetic Models.- New Approaches to Uptake by Heterogeneous Perfused Organs: From Linear to Saturation Kinetics.- Basic Principles Underlying Radioisotopic Methods for Assay of Biochemical Processes in Vivo.- Tracer Studies of Peripheral Circulation.- Tracer Kinetic Modeling in Positron Computed Tomography.- Pharmacokinetic Models and Positron Emission Tomography: Studies of Physiologic and Pathophysiologic Conditions.- Kinetic Analysis of the Uptake of Glucose and Some of Its Analogs in the Brain Using the Single Capillary Model: Comments on Some Points of Controversy.- The Use of 11C-Methyl-D-Glucose for Assessment of Glucose Transport in the Human Brain: Theory and Application.- The Indicator Dilution Method: Assumptions and Applications to Brain Uptake.- Measurement of Ligand-Receptor Binding: Theory and Practice.- Acknowledgements.