It is our pleasure to present this special volume on tissue engineering in the series Advances in Biochemical Engineering and Biotechnology. Thisvolume re?ects the emergence of tissue engineering as a core discipline of modern biomedical engineering, and recognizes the growing synergies between the technological developments in biotechnology and biomedicine. Along this vein, the focusof thisvolume istoprovide abiotechnology driven perspective on cell engineering fundamentals while highlighting their signi?cance in p- ducing functional tissues. Our aim is to present an overview of the state of the art of a selection of these technologies, punctuated with current applications in the research and development of cell-based therapies for human disease. To prepare this volume, we have solicited contributions from leaders and experts in their respective ?elds, ranging from biomaterials and bioreactors to gene delivery and metabolic engineering. Particular emphasis was placed on including reviews that discuss various aspects of the biochemical p- cesses underlying cell function, such as signaling, growth, differentiation, and communication. The reviews of research topics cover two main areas: cel- lar and non-cellular components and assembly; evaluation and optimization of tissue function; and integrated reactor or implant system development for research and clinical applications. Many of the reviews illustrate how bioche- cal engineering methods are used to produce and characterize novel materials (e. g. genetically engineered natural polymers, synthetic scaffolds with ce- type speci?c attachment sites or inductive factors), whose unique properties enable increased levels of control over tissue development and architecture.

Covers trends in modern biotechnology All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from Chemistry, Biochemistry, Microbiology, Genetics, Chemical Engineering and Computer Science, are treated More information as well as the electronic version available at springeronline.com

Inhalt
Tissue Assembly Guided via Substrate Biophysics: Applications to Hepatocellular Engineering.- Polymers as Biomaterials for Tissue Engineering and Controlled Drug Delivery.- Interface Tissue Engineeringand the Formulation of Multiple-Tissue Systems.- Cell Instructive Polymers.- Cellular to Tissue Informatics: Approaches to Optimizing Cellular Function of Engineered Tissue.- Review: Biodegradable Polymeric Scaffolds. Improvements in Bone Tissue Engineering through Controlled Drug Delivery.- Biopolymer-Based Biomaterials as Scaffolds for Tissue Engineering.