THE TESTIS: FROM STEM CELL TO SPERM FUNCTION presents the proceedings of the XVth Testis Workshop held in Louisville, Kentucky. The proceedings review the state-of-the-art analysis of testis development and function.

Klappentext

The Testis: From Stem Cell to Sperm Function presents the proceedings of the XVth Testis Workshop held in Louisville, Kentucky. The proceedings review the state-of-the-art analysis of testis development and function. Topics covered include testis development and differentiation, paracrine and endocrine interactions, genetics and cell biology of spermatogenesis, epididymal maturation and fertilization, and genetic defects and remedies.

Inhalt
Preface.- Contributors.- Prologue.- 1. Unlocking the Mysteries of Male Reproductive Function: How Far Have We Come and Where Are We Going?.- 2. Spermatogenesis After the Millennium.- I. Testis Development and Differentiation.- 3. Sry and the Testis: Molecular Pathways of Organogenesis.- 4. MIS Actions in the Developing Testis.- 5. Regulation of the Differentiation of the Undifferentiated Spermatogonia.- 6. Regulation of Growth and Survival in the Mammalian Germline.- II. Paracrine and Endocrine Interactions.- 7. Synthesis, Fate, and Proposed Function of Clusterin (SGP-2) in the Testis.- 8. HRT for the Aging Male: A Therapy That Has Come of Age?.- 9. Androgen Replacement in Young Men.- III. Genetics and Cell Biology of Spermatogenesis.- 10. Developmental Genetics of Spermatogenesis in the Nematode Caenorhabditis elegans.- 11. Regulation of Meiosis and Spermatid Differentiation in Drosophila Primary Spermatocytes.- 12. HSP70 Chaperones in Spermatogenesis.- 13. Characterization of the Testicular Histone-Binding Protein, NASP.- 14. The Actin-Bundling Protein Espin and Its Role in the Ectoplasmic Specialization.- IV. Epididymal Maturation and Fertilization.- 15. Regulation of Epididymal Function by Testicular Factors: The Lumicrine Hypothesis.- 16. Aging Causes Structural and Functional Alterations in the Epididymis.- 17. The Molecular Basis of SpermEgg Interactions.- V. Genetic Defects and Remedies.- 18. Heritable Sperm Degeneration in the Domestic Fowl.- 19. The DAZ Gene Family and Germ-Cell Development.- 20. Genetic Defects of Male Infertility and ICSI.- 21. Spermatids: Clinically Useful Gametes?.- 22. Effect of Embryo Culture on Imprinted Gene Expression in the Preimplantation Mouse Embryo.- Author Index.