With an extraordinary need for early intervention and prevention to slow or halt its progression, metabolic syndrome is one of the most challenging health problems. Only through an understanding of the science underlying this syndrome can successful interventions be developed and implemented.

This book covers the most important clinical and bench science aspects of metabolic syndrome. Coverage includes updated clinical views on the syndrome, its definition, current and future treatment options, and a critical evaluation of the current status of each of the syndrome components, including the latest knowledge of casual mechanisms.

The writers stimulate new thinking concerning the underlying mechanisms and encourage heightened efforts to develop new therapeutics, potentially targeting uniquely intersecting pathways.

Editors and authors are renowned experts from the basic and clinical sciences Provides state-of-the-art the overview of the metabolic syndrome Details both the basic and clinical science surrounding the syndrome Offers a cross disciplinary analysis on intersecting pathways that play a role in the metabolic syndrome Includes supplementary material: sn.pub/extras

Inhalt
Metabolic SyndromePast and Future.- Metabolic SyndromePast and Future.- Epidemilogy And Clinical Treatment: Issues In Defining And Treating The Metabolic Syndrome.- Metabolic Syndrome.- The Role of Obesity in Insulin Resistance.- Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery.- Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease.- The Sympatho-Adrenal System in the Metabolic Syndrome.- Endothelial Function, Inflammation, and Dyslipidemia.- Insulin Action and Endothelial Function.- Macro- and Microvascular Disease in an Insulin-Resistant Pre-Diabetic Animal Model.- High-Sensitivity C-Reactive Protein and the Metabolic Syndrome.- Insulin Signaling in Adipocytes and the Role of Inflammation.- Insulin Resistance and Dyslipidemia.- InsulinSecretion and Action: Underlying Mechanisms of the Metabolic Syndrome.- Pancreatic Islet Pathophysiology and Pathology in Obesity.- Glucagon-like Peptides and Insulin Sensitivity.- The Relationship Between the Insulin Receptor Substrates and Metabolic Disease.- Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase.- Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance.- Alterations in Atypical Protein Kinase C Activation in Insulin Resistance Syndromes.- The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus.- Chronomics of the Metabolic Syndrome.