It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Klappentext

Influential researchers comprehensively survey the basic and clinical aspects of the insulin-like growth factor system. Their state-of-the-art synthesis of a broad range of IGF research illuminates the interplay among ligands, receptors, and binding proteins, each exerting both the local and systemic effects that constitute this complex system. The book examines in detail not only the molecular biology, the biological actions, and the physiology of the various IGF systems, but also the clinical aspects of the IGF system, ultimately producing a useful paradigm for the investigation of related hormone, growth factor, and cytokine signaling systems. The IGF System: Molecular Biology, Physiology, and Clinical Applications is the first extended treatment of the IGF system in many years and is designed to serve as the new standard reference-of-choice for all basic and clinical investigators, as well as practicing physicians treating a range of human diseases, including cancer, diabetes, and neurodegenerative disorders.

Inhalt
1 Historical Perspective: The Origins and Development of the Somatomedin Hypothesis.- I Molecular Biology of the IGF System.- 2 Molecular Biology of IGF-I and IGF-II.- 3 Regulation of IGF Gene Expression.- 4 Molecular Biology of the Type 1 IGF Receptor.- 5 Molecular Biology of the IGF-II/Mannose-6-Phosphate Receptor.- 6 Molecular Biology of the IGF Binding Proteins.- II Biological Actions of the IGFs.- 7 IGF-I Receptor Function: Transducing the IGF-I Signal into Intracellular Events.- 8 Type 2 IGF Receptor-Mediated Events.- 9 Alternative IGF-Related Receptors.- 10 IGF Binding Proteins as Modulators of IGF Action.- 11 IGF-Independent Actions of the IGF Binding Proteins.- 12 IGF Binding Proteins and Extracellular Matrix.- 13 Biological Actions of Proteolytic Fragments of the IGF Binding Proteins.- 14 The IGF Binding Protein Superfamily.- 15 IGFs and Cell Growth.- 16 Posttranslational Modification of the IGF Binding Proteins.- III IGF Physiology.- 17 IGFs in the Female Reproductive System.- 18 The IGF Axis in the Male Reproductive System.- 19 IGFs and the Nervous System.- 20 IGF System Components and Their Role in Bone Metabolism.- 21 IGFs and Skeletal Muscle.- 22 IGFs and the Digestive Tract.- 23 Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models.- IV Clinical Aspects of the IGFs.- 24 Metabolic Effects of IGFs.- 25 Clinical Uses of IGF-I and IGF Binding Protein Assays.- 26 IGF Binding Protein Proteolysis in Various Clinical States.- 27 IGF Deficiency.- 28 Tumor Hypoglycemia Linked to IGF-II.- 29 IGFs in the Evaluation of Acromegaly.- 30 IGF in the Treatment of Diabetes.- 31 IGF-I Treatment of Growth Hormone Insensitivity.