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This special issue of Molecular and Cellular Biochemistry our their mentor. The ex-students and trainees came from contains original research articles and review papers which all over Canada, the United States, Japan, Slovakia, Ger were invitedfrom the participants ofa recent meeting organ many, the Czech Republic, Estoniaand the Netherlands. The izedto honourthe 60th birthdayofNaranjan S. Dhalla, Ph.D., meeting wasjudged to be an overwhelming success in terms M.D. (Hon.). The meeting, organized by Drs. Morris Karma ofthe scientific content as well as collaborative interactions zyn (London), Grant Pierce (Winnipeg) and Balwant Tuana initiated. (Ottawa), was held at the Best Western Lakeside Inn in We gratefully acknowledge the financial support from Kenora, Ontario, Canada from August 23-25th, 1996. The Pfizer, MerckFrosst, Astra, Ciba-Geigy, the Heart and Stroke meeting was entitled 'The Cellular Basis of Cardiovascular Foundation of Manitoba, the Medical Research Council of Function in Health and Disease'. There were over40 invited Canada, St. Boniface Research Foundation, the NRC Insti speakers from 15 different countries present at the meet tute for Biodiagnostics, the ManitobaHealth Research Coun ing and it was attended by over 280 people. Keynote lectures cil and various sources within the University of Manitoba.

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I: Vascular changes in health and disease.- Analysis of responses to human synthetic adrenomedullin and calcitonin gene-related peptides in the hindlimb vascular bed of the cat.- Effect of short-term treatment with a monoclonal antibody to P-selectin on balloon cathether-induced: Intimal hyperplasia, re-endothelialization, and attenuation of endothelial-dependent relaxation.- Differential regulation of G-protein expression by vasoactive peptides.- Endothelin contraction in pig coronary artery: Receptor types and Ca2+-mobilization.- Activation of the neutrophil and loss of plasma glutathione during Mg-deficiency modulation by nitric oxide synthase inhibition.- Velocity of translation of single actin filaments (AF) by myosin heads from antigen-sensitized airway smooth muscle.- Smooth muscle contractility and protein tyrosine phosphorylation.- Coronary artery smooth muscle in culture: migration of heterogeneous cell populations from vessel wall.- An overview of the influence of ACE inhibitors on fetal-placental circulation and perinatal development.- II: Cardiac mechanisms in health.- Differential nature of cross-talk among three G-coupled receptors regulating adenylyl cyclase in rat cardiomyocytes chronically exposed to receptor agonists.- Reversal of phosphate induced decreases in force by the benzimidazole pyridazinone, UD-CG 212 CL, in myofilaments from human ventricle.- Expression of fibroblast growth factor receptor-1 in rat heart H9c2 myoblasts increases cell proliferation.- Identification of an HMG-like protein involved in regulation of Na+/H+ exchanger expression.- Cytochemical and immuoncytochemical localization of Na,K-ATPase ? subunit isoenzymes in the rat heart.- Estradiol modulates the sodium pump in the heart sarcolemma.- Thyroid hormones differentiallyaffect sarcoplasmic reticulum function in rat atria and ventricles.- Dietary and physiological studies to investigate the relationship between calcium and magnesium signalling in the mammalian myocardium.- Biological significance of phosphorylation and myristoylation in the regulation of cardiac muscle proteins.- Contributions of increased efficiency and capacity of protein synthesis to rapid cardiac growth.- Cell-cycle dependent anti-FGF-2 staining of chicken cardiac myocytes: Movement from chromosomal to cleavage furrow- and midbody-associated sites.- An endogenous positive inotropic factor (EPIF) from porcine heart: Its effects on sarcoplasmic reticular (SR) Ca2+ metabolism.- III: Subcellular changes in cardiomyopathies and heart failure.- Prostaglandins attenuate cardiac contractile dysfunction produced by free radical generation but not by hydrogen peroxide.- Changes in fatty acid compositions of myocardial lipids in rats with heart failure following myocardial infarction.- Mechanisms that may be involved in calcium tolerance of the diabetic heart.- Increases of T-type Ca2+ current in heart cells of the cardiomyopathic hamster.- Myocardial functional preservation during ischemia: Influence of beta blocking agents.- Phosphorylation by protein kinase C and the responsiveness of Mg2+-ATPase to Ca2+ of myofibrils isolated from stunned and non-stunned porcine myocardium.- Is there a link between impaired glucose metabolism and protein kinase C activity in the diabetic heart?.- A new technique of coronary artery ligation: Experimental myocardial infarction in rats in vivo with reduced mortality.- Adriamycin depresses in vivo and in vitro phos-phatidylethanolamine N-Methylation in rat heart sarcolemma.- A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy.- Early fetal like slow Na+ current in heart cells of cardiomyopathic hamster.- Na+-H+ exchange inhibition at reperfusion is cardioprotective during myocardial ischemia-reperfusion; 31PNMR studies.- Increased gene expression of plasminogen activators and inhibitors in left ventricular hypertrophy.- Cardiac hypertrophy: Old concepts, new perspectives.- Characteristics of the myocardial PM-FABP: Effect of diabetes mellitus.- Cardiomyopathies and mitochondrial DNA mutations.- Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: Role of free radicals.- Ischemic preconditioning is not additive to preservation with hypothermia or crystalloid cardioplegia in the globally ischemic rat heart.- IV: Cellular biochemistry in non-cardiovascular tissues.- Regulation of Ca2+ homeostasis by glucose metabolism in rat brain.- Age- and sex-related differences in nuclear lipid content and nucleoside triphosphatase activity in the JCR:LA-cp corpulent rat.- Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion.- Index to Volume 176.