This volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Systems Medicine: Methods and Protocols is a valuable resource for the scientific community that will help researchers work together toward the further advancement of achieving the goal of promoting global health.

Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
Mass Spectrometry-Based Proteomics for Biomarker Discovery.- Integration of Omics and Phenotypic Data for Precision Medicine.- Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the Era of Systems Medicine.- Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics.- Applications of Quantitative System Pharmacology Modeling to Model Informed Drug Development.- Combating Viral Diseases in the Era of Systems Medicine.- Toxicity Analysis of Pentachlorophenol Data with a Bioinformatics Tool Set.- Virtual Populations for Quantitative Systems Pharmacology Models.- Quantitative Systems Toxicology and Drug Development: The DILIsym Experience.- Introduction to Genomic Network Reconstruction for Cancer Research.- Learning in Medicine: The Importance of Statistical Thinking.- Development and Applications of Interoperable Biomedical Ontologies for Integrative Data andKnowledge Representation and Multiscale Modeling in Systems Medicine.- Systems Biology to Address Unmet Medical Needs in Neurological Disorders.- Informatics in Medical Product Regulation: The Right Drug at the Right Dose for the Right Patient.- Personal Dense Dynamic Data Clouds Connect Systems Bio-Medicine to Scientific Wellness.- Educational Needs for Quantitative Systems Pharmacology Scientists.