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Suppression and Regulation of Immune Responses

  • Kartonierter Einband
  • 492 Seiten
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This book highlights recent advances in the identification, characterization, and generation of regulatory cells not only of the T... Weiterlesen
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This book highlights recent advances in the identification, characterization, and generation of regulatory cells not only of the T cell lineage but also of other origins, as well as the role of several suppressive molecules in immunoregulation.

Over the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation. In Suppression and Regulation of Immune Responses: Methods and Protocols, expert researchers highlight recent advances in the identification, characterization, and generation of regulatory cells not only of the T cell lineage but also of other origins such as B, NK, myeloid, and dendritic cells, as well as the role of several suppressive molecules in immunoregulation. Particular emphasis is placed on the characterization of the molecular mechanisms and the therapeutic applications of regulatory cells and molecules in human diseases. Written as a volume in the highly successful Methods in Molecular Biology(TM) series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Comprehensive and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols serves as a key reference for scientists seeking a way toward greater control over the enormous power of the complex and vital immune system.

From the reviews:

This is a highly informative book, packed with a wealth of information covering all aspects of immune suppression and regulatory mechanisms. There is a diverse array of protocols offered, which are generally clear and easy to follow. the wealth of information and literature reviews included make this book worth purchasing for those working in this field. (Andrew Vaughan, Immunology News, August, 2011)


Part I: Regulatory Cells

1. Natural and Induced T CD4+CD25+FOXP3+ Regulatory T Cells
Lucienne Chatenoud

2. Polyclonal Expansion of Human CD4+CD25+ Regulatory T Cells
Petra Hoffmann, Ruediger Eder, and Matthias Edinger

3. Methods for In vitro Generation of Human Type 1 Regulatory T (Tr1) Cells
Silvia Gregori, Maria Grazia Roncarolo, and Rosa Bacchetta

4. Ex vivo Generation of Regulatory T-Cells: Characterization and Therapeutic Evaluation in a Model of Chronic Colitis
Fridrik Karlsson, Sherry Jackson, Laura Gray, Songlin Zhang, and Matthew B. Grisham

5. Phenotypic and Functional Characterization of CD8+ T Regulatory Cells
Séverine Ménoret, Carole Guillonneau, Séverine Bezié, Lise Caron, Ignacio Anegon, and Xian-Liang Li

6. Regulatory CD4- CD8- Double Negative T Cells
Edward Y. Kim, Stephen C. Juvet, and Li Zhang

7. Identifying Regulatory B Cells (B10 Cells) that Produce IL-10 in Mice
Takashi Matsushita and Thomas F. Tedder

8. DCs in Immune Tolerance in Steady-State Conditions
Tomohiro Fukaya, Hideaki Takagi, Honami Taya, and Katsuaki Sato

9. Plasmacytoid Dendritic Cells in Tolerance
Eric Gehrie, William Van der Touw, Jonathan S. Bromberg, and Jordi C. Ochando

10. In vitro Generated DC with Tolerogenic Functions: Perspectives for In vivo Cellular Therapy
Cees van Kooten and Kyra A. Gelderman

11. Preparation of Mouse Bone Marrow-Derived Dendritic Cells with Immunoregulatory Properties
Mercedes Segovia, Maria Cristina Cuturi, and Marcelo Hill

12. Myeloid Derived Suppressor Cells (MDSC): Characterization and Expansion in Models of Endotoxemia and Transplantation
Nicolas Van Rompaey and Alain Le Moine

13. Human Regulatory Macrophages
James A. Hutchinson, Paloma Riquelme, Edward K. Geissler, and Fred Fändrich

14. NKT and Tolerance
Julien Diana, Lucie Beaudoin, Anne-Sophie Gautron, and Agnès Lehuen

15. Anti-Inflammatory and Immunosuppressive Functions of Mast Cells
Janet Kalesnikoff and Stephen J. Galli

16. A Mesenchymal Stem Cell Potency Assay
Joy Jiao, Jack M. Milwid, Martin L. Yarmush, and Biju Parekkadan

17. In Vitro Analyses of the Immunosuppressive Properties of Neural Stem/Progenitor Cells Using Anti-CD3/CD28 Activated T Cells
Virginie Bonnamain, Isabelle Neveu, and Philippe Naveilhan

Part II: Regulatory Molecules

18. Immunoregulatory Properties of Heme Oxygenase-1
Philippe Blancou, Virginie Tardif, Thomas Simon, Séverine Rémy, Leandro Carreño, Alexis Kalergis, and Ignacio Anegon

19. Indoleamine, 2,3-Dioxygenase, and Regulatory Function: Tryptophan Starvation and Beyond
Ciriana Orabona and Ursula Grohmann

20. Regulatory T Cell Enrichment by IFN- Conditioning
Gang Feng, Kathryn J. Wood, and Andrew Bushell

21. Transforming Growth Factor-Beta: Recent Advances on Its Role in Immune Tolerance
Pierre-Yves Mantel and Carsten B. Schmidt-Weber

22. Induction of Tolerogenic Dendritic Cells by NF- B Blockade and Fc Receptor Modulation
Leandro J. Carreño, Claudia A. Riedel, and Alexis M. Kalergis

23. Fine-Tuning Antitumor Responses through the Control of Galectin-Glycan Interactions: An Overview
Mariana Salatino and Gabriel A. Rabinovich

24. Regulation of Lymphocytes by Nitric Oxide
Christian Bogdan

Part III: Physiopathological Situations

25. Pregnancy: Tolerance and Suppression of Immune Responses
Ana Claudia Zenclussen, Anne Schumacher, Maria Laura Zenclussen, Ana Teles, Nadja Brachwitz, Pablo Casalis, Tarek El-Mousleh, Federico Jensen, and Katja Woidacki

26. Organ Transplantation: Modulation of T Cell Activation Pathways Initiated by Cell Surface Receptors to Suppress Graft Rejection
Kathleen Weatherly and Michel Y. Braun

27. Immunosuppressive Mechanisms During Viral Infectious Diseases
Ghanashyam Sarikonda and Matthias G. von Herrath

28. Ocular Immune Privilege Sites
Sharmila Masli and Jose L. Vega

29. Immunoprivileged Sites: The Testis
Monika Fijak, Sudhanshu Bhushan, and Andreas Meinhardt


Titel: Suppression and Regulation of Immune Responses
Untertitel: Methods and Protocols
EAN: 9781493961634
ISBN: 1493961632
Format: Kartonierter Einband
Herausgeber: Humana Press
Genre: Medizin
Anzahl Seiten: 492
Gewicht: 916g
Größe: H254mm x B178mm x T26mm
Jahr: 2016
Auflage: Softcover reprint of the original 1st ed. 2011

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