Nanocrystals have been established as an important cancer diagnosis and therapeutic tool due to their ability to deliver poorly soluble drugs with sustained release, low toxicity, and flexibility of administration. In this book, the importance and current status of nanocrystals in cancer therapy are presented, along with challenges, and future prospects.

The book focuses on several therapies of nanocrystals, including anticancer, immunotherapy, radiotherapy, biotheranostics, targeted therapy, photothermal, and photodynamic. Further, different imaging and diagnostics using nanocrystals are mentioned, including magnetic resonance imaging (MRI), computed tomography (CT), biosensing, and luminescence. Finally, the limitations and potential solutions of nanocrystals in the field of cancer theranostics are also discussed.

Provides recent information on nanocrystals-based cancer therapeutics and diagnostics Covers synthesis and properties of nanocrystals and related techniques such as drug delivery and targeted therapy Uses language accessible to readers with varying backgrounds

Autorentext

Dr Sudip Mukherjee: Sudip Mukherjee, PhD, MRSC, is an assistant professor at the School of Biomedical Engineering at the Indian Institute of Technology, BHU (IIT BHU). Dr Mukherjee completed his PhD from CSIR-IICT, Hyderabad, India in 2017 followed by postdoctoral position at Rice University, USA in 2022. His present research interests include the development of advanced biomaterials for cell therapy and drug/gene delivery in diabetes, cancer theranostics, angiogenesis, and immunomodulatory applications. He is member of the Royal Society of Chemistry, UK and AACR, USA. He has published 67 publications, 5 books, 12 book chapters, 15 patents. He serves as an associate editor for the BMC Cancer and Frontiers in Chemistry.

Dr. Vijay Sagar Madamsetty obtained his Ph.D. in chemical science from the Academy of Scientific and Innovative Research (AcSIR), India. With a fervent dedication to pioneering research in nanomedicine spanning 15 years, he embarked on his journey at the Council of Scientific and Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT). Currently, he is a senior scientist at PolyaRNA Therapeutics in Cambridge, Massachusetts, USA. Dr. Madamsetty's career highlights include his tenure at CSL Seqirus, where he focused on the development of SamRNA-LNP-based nano vaccines targeting influenza diseases. Presently, his focus has shifted towards advancing mRNA-LNP-based vaccines and therapeutics.

Dr. Rakesh C Reddy Meka is a Scientist, with over 15 years of academic & industrial research experience. Special expertise in Immunology, Cell and gene therapy, vaccine development and Nanotechnology. Experience in Cell based assay development techniques with substantial experience in cell and molecular biology, in-vitro, and in-vivo techniques. Involved in the COVID vaccine development project (COVAXIN) and CAR T therapy products. He published peer reviewed articles in RSC, Elsevier, and ACS publications.

Lipi Pradhan is a research scholar presently pursuing her Ph.D. degree in the School of Biomedical Engineering, IIT BHU, Varanasi. She has earned her M.Sc. in Zoology from the Department of Zoology, Ranchi University. Her research interests involved designing cell-based therapy for treating rare genetic disorders and green synthesis of nanoparticles for various biomedical applications.

Devyani Yenurkar is a Prime Minister's Research Fellow (PMRF) in the School of Biomedical Engineering at the Indian Institute of Technology IIT(BHU). She received her master's degree in pharmacy (Pharmaceutics) from SNDT University, Mumbai. Her present interest in research includes work with nanomaterials for their potential applications in the field of blood anticoagulation and thrombosis.

Sumit Manna completed his B.Sc. and M.Sc. in Human Physiology from the University of Calcutta, West Bengal. Currently, he is a research scholar pursuing his Ph.D. degree in the School of Biomedical Engineering at IIT (BHU), Varanasi. His research work focuses on the development of cell-based therapies for the treatment of genetic disorders.

Durba Banerjee is currently pursuing her Ph.D. in School of Biomedical Engineering at IIT BHU Varanasi, where her research is dedicated to cell- based therapies for tissue regeneration and internal wound healing. She holds a Master's a degree in Biotechnology, from Gautam Buddha University, Greater Noida

Inhalt

Chapter 1: Introduction.- Chapter 2: Types of Nanocrystals, synthesis and properties: Organic nanocrystals, Inorganic nanocrystals, Hybrid Nanocrystals.- Chapter 3: Nanocrystals application in cancer therapy: Nanocrystals as drug delivery vehicles; Nanocrystals in targeted therapy; Nanocrystals as anticancer agents.- Chapter 4: Immunomodulation, immunotherapy and biotherapeutics through nanocrystals.- Chapter 5: Rediotherapeutics applications of nanocrystals: PTT, PDT.- Chapter 6: Imaging (magnetic resonance imaging (MRI), computed tomography (CT), biosensing, and luminescence), diagnostics and theranostics applications of nanocrystals.- Chapter 7: Biophysical characterization of Nanocrystals.- Chapter 8: Toxicity, Clinical Studies of Nanocrystals, Conclusion and Future Scope.