Subcellular Biochemistry

Corpora non agunt nisi fixata. This old saying of Ehrlich's describing the physi ological role of receptors and their ligands might be paraphrased into Corpora non ambulant nisi fixata when considering lipid transport between and within cells. Volume 16 of Subcellular Biochemistry is intended to bring the reader up to date with this young field. Indeed, lipid transfer proteins have only recently become the subject of a more systematic study. In this book the current status and the emerging trends are discussed. Chapters cover protein-mediated transfer of fatty acids, phospholipids, phosphatidylinositol, glycolipids, dolichol, retinoids, and cholesterol in animal, plant, yeast, and other eukaryotic cells. Details are included of the study of lipid transport proteins by means of fluorescent phos pholipid analogues and of the lipid transfer proteins as probes of membrane structure and function, as well as spontaneous lipid transfer as it occurs between biological membranes. Some of the chapters should be read in conjunction with Volume 13 of this series, devoted to fluorescence studies on biological mem branes, in particular Chapter 2 (Somerharju et al. ) concentrating on studies in which fluorescent phospholipid analogues have been used. Chapter 10 (Bill heimer and Reinhart), dealing with cholesterol trafficking, should be compared with Chapter 12 of Volume 13 (Van Blitterswijk), pointing to the existence of a preferential association of cholesterol with sphingomyelin, which drags choles terol to the plasma membrane. In one chapter (Chapter 8: Van Dessel et al.

Klappentext

Discusses the current status and emerging trends of the young field of study. Chapters explore the protein-mediated transfer of fatty acids, phospholipids, phosphatidylinositol, glycolipids, dolichol, retinoids, and cholesterol in animal, plant, yeast, and other eukaryotic cells. Provides details on

Inhalt
1: Nonenzymatic Proteins Mediating Intracellular Lipid Transport and Metabolism: Current Status and Emerging Trends.- 2: Application of Fluorescent Phospholipid Analogues to Studies on Phospholipid Transfer Proteins.- 3: Phospholipid Transfer Proteins as Probes of Membrane Structure and Function.- 4: Intracellular Transfer of Phospholipids, Galactolipids, and Fatty Acids in Plant Cells.- 5: Glycolipid Transfer Protein in Animal Cells.- 6: Transport and Metabolism of Phosphatidylinositol in Eukaryotic Cells.- 7: Intracellular Fatty-Acid-Binding Proteins: Characteristics and Function.- 8: Intracellular and Extracellular Flow of Dolichol.- 9: Phospholipid Transfer in Microorganisms.- 10: Intracellular Trafficking of Sterols.- 11: Spontaneous Transfer of Lipids between Membranes.- 12: Extra- and Intracellular Transport of Retinoids.