Studies on Diabetes examines how increased oxidative and nitrosative stress one of the leading causes of diabetes complications pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease. Their contributions represent a wealth of knowledge on and research into how diabetes triggers metabolic abnormalities that lead to hyperactivation of cellular and mitochondrial pathways that ultimately result in oxidative and nitrosative stress that left un-neutralized, results in tissue damage. Each chapter provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease. Potential treatments for diabetes complications from animal models to the patient will also be discussed. This is essential reading for researchers and clinicians in endocrinology, diabetes, vascular disease and oxidative stress.

Reveals how increased oxidative and nitrosative stress pathologically affects multiple tissues in the body Provides insights to the complicated mechanisms responsible for diabetes complications and vascular disease and discusses potential treatments Presents worldwide expertise from leading investigators in the fields of basic and clinical research in diabetes and vascular disease Includes supplementary material: sn.pub/extras

Autorentext

Professor Irina G. Obrosova joined Kiev State University to read Biology and then went on to complete a PhD in Biochemistry at Kiev State University. After completing an appointment as a Junior Research Scientist, she was appointed Senior Research Scientist in the Department of Diabetology, Institute of Endocrinology and Metabolism, Kiev. Her exceptional scientific qualities led her promotion to the position of Leading Research Scientist, Department of Diabetology, Institute of Endocrinology and Metabolism.

Professor Martin J. Stevens completed his MD at the Diabetes Department, Kings College Hospital, London; his thesis focused on complications of the diabetic foot. He then moved to the Endocrinology Division at the University of Michigan where he became Associate Professor of Medicine. There, he served as Director of the Diabetes Complications Clinic and Associate Director for the Juvenile Diabetes Research Foundation's Center for Diabetes Excellence. He returned to the United Kingdom as Professor of Medicine at the University of Birmingham and Birmingham Heartlands Hospital. His research interests focus on the prevention and treatment of obstructive sleep apnea, diabetic neuropathy and its cardiovascular consequences and the foot complications of diabetes.

Dr. Mark Yorek received his Ph.D. in Biochemistry from the University of North Dakota where he studied glucose metabolism and published the first papers on regulation of gluconeogenesis using isolated rabbit hepatocytes. He completed a postdoctoral fellowship at the University of Iowa in Biochemistry where he studied fatty acid metabolism. He joined the Department of Internal Medicine at the University of Iowa and began his studies relating to diabetic vascular and neural complications, eventually becoming a Professor there. His laboratory is located at the VA Medical Center in Iowa City where he is the Associate Chief of Staff for Research.

Inhalt

1. Oxidative Stress and Diabetes-induced Vascular Dysfunction: Role in Diabetic Neuropathy.- 2. Cerebrovascular Disease in Type 1 Diabetes: Role of Oxidative Stress.- 3. Complications in the Coronary Circulation Associated with Diabetes.- 4. Chronic Kidney Disease and Cardiovascular Risk.- 5. Mitochondria and Oxidative Stress in Diabetes.- 6. Optimal Measures of Small Fiber Neuropathy in Diabetic Polyneuropathy.- 7. Oxidative Stress and Complications of the Diabetic Foot.- 8. Encephalopathies Accompanying Type 1 and Type 2 Diabetes.- 9. Oxidative Stress, Inflammation and Endothelial Dysfunction: The Link Between Obstructive Sleep Apnoea and Vascular Disease in Type 2 Diabetes.- 10. Taurine Treatment for Complications of Diabetes.- 11. Oxidative Stress and Cardiovascular Disease in Diabetes.- 12. Oxidative Stress in Diabetes Mellitus and Possible Interventions.