Recent advances in cellular and molecular biology have markedly increased our understanding of normal and abnormal hypothalamicpituitarytesticular function. Like other volumes in the Contemporary Endocrinology series, the goal of Male Hy- gonadism: Basic, Clinical, and Therapeutic Principles is to link current knowledge of basic biology to the practice of medicine. The development of new methods for testost- one replacement has substantially increased the number of men who are seeking to determine whether they are hypogonadal, and who are using testosterone replacement therapy, thus mandating a broader understanding of testosterone deficiency. The chapters of this book were contributed by authors from around the world, and from various scientific and clinical disciplines, who have devoted their careers to the study of the physiology and pathophysiology of the male. Thus, this comprehensive and focused volume is intended for a wide audience encompassing both basic scientists and practicing clinicians. Its scope will provide a wealth of information for students and fellows as well.

Includes supplementary material: sn.pub/extras

Klappentext
Recent advances in cellular and molecular biology have substantially increased our understanding of normal and abnormal hypothalamic-pituitary-testicular function. In Male Hypogonadism: Basic, Clinical, and Therapeutic Principles, well-known clinicians and basic scientists comprehensively explain and apply these new insights to the treatment of hypogonadal men. The authors focus on the specific causes of gonadotropin deficiency and testicular failure arising from disorders of the brain and the testis and from gene defects and chronic illness. Additional chapters describe the endocrine mechanism for the decline of testicular function with aging, summarize the data supporting the negative impact of environmental toxins on testicular function, and discuss the testicular consequences of exercise and obesity. Also included is an overview of androgen replacement therapy and a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men.
Comprehensive and highly practical, Male Hypogonadism: Basic, Clinical, and Therapeutic Principles lucidly interprets a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.

Inhalt
1 Neuroendocrine Control of Testicular Function.- 2 Leydig Cell Function in Man.- 3 Spermatogenesis and Its Regulation in Higher Primates.- 4 Normal and Delayed Puberty.- 5 Congenital Hypogonadotropic Hypogonadism: Clinical Features and Pathophysiology.- 6 Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and Their Receptors.- 7 Hypogonadism in Males With Congenital Adrenal Hyperplasia.- 8 Male Hypogonadism Resulting From Disorders of the Pituitary and Suprasellar Region.- 9 Klinefelter's Syndrome.- 10 Cryptorchidism.- 11 Hypogonadism in Men With HIV-AIDS.- 12 Hypogonadism in Men With Chronic Renal Failure.- 13 Male Hypogonadism Resulting From Cancer and Cancer Treatments.- 14 An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men.- 15 Environmental Causes of Testicular Dysfunction.- 16 Exercise and Male Hypogonadism: Testosterone, the HypothalamicPituitaryTesticular Axis, and Physical Exercise.- 17 Testosterone, SHBG, and the Metabolic Cardiovascular Syndrome.- 18 Androgen Replacement Therapy in Hypogonadal Men.- 19 Stimulation of Spermatogenesis in Hypogonadotropic Men.