This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer.

Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

Reviews the pathology of early gastric cancers Explores the stem cell biology in the context of upper gastrointestinal cancers Discusses therapeutic modalities in esophageal squamous cell carcinoma and early esophageal cancer Includes supplementary material: sn.pub/extras

Autorentext

Professor Sir Nicholas Wright's research is in the field of gastrointestinal stem cells and cancer. He was Professor of Pathology at the Royal Postgraduate Medical School at the Hammersmith Hospital, and then became the Dean of the Royal Postgraduate Medical School before becoming the Deputy Principal of the Imperial College School of Medicine in 1998. Sir Nicholas then served as Warden of Barts and the London, Queen Mary's School of Medicine and Dentistry from 2001 to 2011. He as served as Group Leader at the Histopathology Unit at Cancer Research UK London Research Institute and was President of the Pathological Society of Great Britain and Ireland and the British Society of Gastroenterology. He was knighted in 2006 for services to medicine. Sir Wright has published over 427 scientific articles and received over 12,939 citations.

Dr. Marnix Jansen is a histopathologist at University College London Hospital (UCLH) and Senior Clinical Fellow at Barts Cancer Institute. He arising young star in the area of upper GI cancer research and he has published 23 scientific papers and has received over 794 citations.

Inhalt

1. Metaplastic tissue changes in the upper GI -Marnix Jansen/ Neil Shepherd.- 2. Clonal expansion of early neoplasia -Stuart McDonald/Nick Wright.- 3. Stem cell dynamics in experimental models -Ed Morissey/Doug Winton.- 4. The gastric cardia: fact or fiction? -Henry Appelmann.- 5. Pathology of early esophageal squamous cell carcinoma (ESCC) -Ryoji Kushima.- 6. Therapeutic modalities for esophageal squamous cell carcinoma- TBD.- 7. The most contentious issues in Barrett's esophagus -Rob Odze/Elizabeth Montgomery.- 8. Pathology of Barrett's esophagus -Sybren Meijer/Michael Vieth.- 9. Genetic risk factors of Barrett's esophagus -TBD.- 10. Screening, early detection and novel diagnostic tools for Barrett's esophagus -Fitzgerald.- 11. Clonal evolution of Barrett's esophagus -Brian Reid.- 12. Endoscopic therapeutic modalities of early esophageal cancer -Jacques Bergman/ David Fleischer.- 13. Pathology of early gastric cancer- Ryoji Kushima/Shigeki Sekine.- 14. Hereditary signet ring cell carcinoma -Fatima Carneiro/Johan Offerhaus.- 15. Experimental models for gastric cancer-Daniel Stange/Jim Goldenring/Timothy Wang.- 16. ESD for early gastric cancer -Ichiro Oda.