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Stem Cells and Their Potential for Clinical Application

  • Kartonierter Einband
  • 282 Seiten
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Proceedings of the NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application, Kyiv and Foros,Ukra... Weiterlesen
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Proceedings of the NATO Advanced Research Workshop on Stem Cells and Their Potential for Clinical Application, Kyiv and Foros,Ukraine, May 2006

This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference's main topics, the book is divided into five chapters - Haematopoietic stem cells and haematopoiesis, Biology of n- haematopoietic stem cells, Stem cells and malignancy, Cell processing; expansion and genetic modification and Clinical haematopoietic stem cell transplantation.

State-of-the-art articles from leading scientists in stem cell and leukaemia research

Contains the East European view on stem cell research

Covers stem cell research - from bench to bedside

Provides novel data in hot areas of science such as stem cell & gene therapy research


This book contains contributions of leading international scientists who participated at the NATO-ASI conference "Stem cells and their potential for clinical application" that was held in Kiev and Simeiz (Ukraine) from August 23 - 31 , 2006. The articles cover a broad range of hot topics in stem cell and leukaemia research. These include the potential of various stem cell types in regenerative and transplantation medicine, different mechanisms of malignant transformation leading to leukaemia development, as well as novel clinical strategies for malignant disease treatment such as adoptive immunotherapy with gene-modified lymphocytes. The mixture of articles by principal scientists from Northern America, as well as Eastern and Western Europe, provides a comprehensive overview on "What's going on?" in various parts of the world in such broadly discussed fields as "stem cell research", "immunotherapy" or "gene therapy". Thus, this compilation should be valuable for readers interested in modern biomedicine who have background knowledge in those areas.

I. HAEMATOPOIETIC STEM CELLS AND HAEMATOPOIESIS. Clonal Dominance After Reconstitution of the Haematopoietic System with Bone Marrow Cells Retrovirally Transduced with Murine CD34 Variants; G.von Keudell et al.- Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Self-Renewal of Early Hematopoietic Progenitor Cells; J. Friel et al.- Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cells (HSC) Compartment; O.I. Gan et al.- Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CDF Injections; I.N. Nifontova et al.- Regulation of Hematopoiesis by Growth Factors; E.R. Stanley.- II. BIOLOGY OF NON-HAEMATOPOIETIC STEM CELLS. Stem Cell Technologies in Gerontological Research; G.M. Butenko.- Osteopetrotic Models for Identifying Genes that Control Bone Resorption; W.Wiktor-Jedrzejczak.- Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine; C. Lange et al.- Epithelial Plasticity of Hepatocytes during Liver Tumor Progression; M. Mikula et al.- Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life; M. Crisan.- III. STEM CELLS AND MALIGNANCY. Stem Cells and Leukemia; V. Bebeshko et al.- Telomere and Stem Cell Biology in Chronic Myeloid Leukemia; S. Balabanov et al.- Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules Enemies or Friends; B. Seliger.-The RUNXI Transcription Factor: A Gatekeeper in Acute Leukemia; C. Stocking et al.- IV. CELL PROCESSING, EXPANSION AND GENETIC MODIFICATION. Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population; N.M. Bilko et al.- Animal Hybrids and Stem Cells Their Use in Biotechnology and Clinical Practice; L.P. Djakonov.- Cryopreservation of Stem Cells; V.I. Grischenko et al.- The M813 Retrovirus Belongs to a Unique Interference Group and is highly Fusogenic; V. Prassolov.- Reconstructing an Anti-TumorImmune Repertoire for Targeted AML Therapy; M. Theobald.- V. CLINICAL HAEMATOPOIETIC STEM CELL TRANSPLANTATION. Experience of Kyiv Center of Stem Cell Transplantation; V.I. Khomenko.- Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors; A.R. Zander et al.-


Titel: Stem Cells and Their Potential for Clinical Application
EAN: 9781402064685
ISBN: 1402064683
Format: Kartonierter Einband
Herausgeber: Springer-Verlag GmbH
Genre: Medizin
Anzahl Seiten: 282
Gewicht: 464g
Größe: H235mm x B155mm x T16mm
Veröffentlichung: 01.02.2008
Jahr: 2008
Auflage: 2008

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