This volume reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Leading experts in the field Thorough description and analysis of research Includes supplementary material: sn.pub/extras

Inhalt
Beta-Cell Expansion and Regeneration.- Pancreas and Islet Development.- Islet and Pancreas Transplantation.- Cell Cycle Regulation in Human Pancreatic Beta Cells.- Islet Regeneration.- Beta-Cell Expansion in Vitro.- Beta Cells from Non-beta Cells.- What Does It Take to Make a Beta Cell?.- Generation of Beta Cells from Acinar Cells.- Generation of Beta Cells from Pancreatic Duct Cells and/or Stem Cells.- Adult Cell Reprogramming: Using Nonpancreatic Cell Sources to Generate Surrogate Beta Cells for Treatment of Diabetes.- Embryonic Stem Cells as a Potential Cure for Diabetes.- Tissue Engineering and Immune Protection.- Functional Tissue Reconstruction with the Use of Biologic Scaffolds.- Immunoisolation in Cell Transplantation.- Prevention of Islet Graft Rejection and Recipient Tolerization.