Autorentext

Ayush Madan is an assistant professor in the Department of Biotechnology at the People's University, Bhopal, and a research assistant at the Institute of Tropical Aquaculture and Fisheries. He has published over 45 book chapters and articles in international journals. His research interests include animal biotechnology, bioprocess engineering, and downstream processing. Sumel Ashique is a researcher in the School of Pharmaceutical Sciences at Lovely Professional University. He has over 200 publications, including eight books and numerous book chapters and journal articles. His research focuses on nanoformulations, targeted drug delivery, probiotics, and postbiotics. Deepika Arora, PhD is the Lab Director at the Regenerative Cell Research Institute. She has published over 19 book chapters and articles in international journals. Her research focuses on cell therapy, regenerative medicine, and tissue engineering. Mantosh Kumar Satapathy, PhD is a postdoctoral researcher in the College of Biomedical Engineering at Taipei Medical University with over a decade of experience. He has published over 20 articles in international journals and conferences. He specializes in cell culture, tissure engineering, nanocomposites, and nanobiotechnology.

Klappentext

Discover the revolutionary potential of stem cell therapy and gain a comprehensive understanding of its applications, challenges, and ethical considerations across various medical fields with Stem Cell Therapeutics, a must-read for anyone interested in the future of medicine. Stem Cell Therapeutics delves into the forefront of medical research, exploring the revolutionary potential of stem cell therapy in combating a wide array of diseases. This comprehensive volume provides a thorough examination of the subject matter, offering insights into the latest advancements, methodologies, and applications of stem cell therapeutics. The book adopts a multidisciplinary approach, drawing upon expertise from fields such as biology, medicine, biotechnology, and bioengineering. Readers can expect to encounter in-depth discussions on the use of stem cells in treating various medical conditions, including neurodegenerative disorders, cardiovascular diseases, autoimmune conditions, and cancer. Each chapter provides a comprehensive overview of the current state of research for each disease, highlighting the challenges, successes, and prospects of stem cell-based therapies. Additionally, the book explores ethical considerations, regulatory frameworks, and commercialization strategies surrounding the field, ensuring a well-rounded understanding of the subject matter for readers at all levels of expertise.

Inhalt

Preface xxix

1 Unraveling the Mechanisms: Insights Into Stem Cell Behavior in Disease Microenvironments 1
Pranshul Sethi, Aniruddha Sen, Sonima, Ayush Madan, Syed Mohsin Waheed and Bibhas Kumar Bhunia

1.1 Introduction 2

1.2 Stem Cell Biology and the Stem Cell Niche 4

1.3 Disease Microenvironments and Their Impact on Stem Cells 9

1.4 Molecular and Cellular Mechanisms 12

1.5 Techniques for Studying Stem Cell Behavior in Diseased States 16

1.6 Stem Cell Dynamics in Various Diseases 19

1.7 Therapeutic Implications 24

1.8 Case Studies 27

1.9 Future Directions 29

2 CRISPR-Cas9 and Beyond: Gene Editing Frontiers in Stem Cell Therapeutics 39
Pranshul Sethi, Sonali Rastogi, Kajal Sherawat, Neetu Panwar, Ayush Madan and Mojahidul Islam

2.1 Introduction 40

2.2 Significance of CRISPR-Cas9 Technology 41

2.3 Overview of Stem Cell Therapeutics 42

2.4 Fundamentals of CRISPR-Cas9 Technology 42

2.5 Ethical and Regulatory Considerations 50

2.6 Applications in Stem Cell Research 51

2.7 Stem Cells: A Therapeutic Frontier 52

2.8 CRISPR-Cas9 in Stem Cell Therapeutics 62

2.9 Beyond CRISPR-Cas9: Emerging Gene Editing Technologies 79

2.10 Ethical, Legal, and Social Implications (ELSI) 84

2.11 Future Prospects and Challenges 95

2.12 Conclusion 100

3 Future Vistas: Revolutionary Technologies and Paradigms in Stem Cell Therapeutics 107
Dattatraya M. Shinkar, Sharayu P. Rathod, Priyanka D. Dabir, Sandip R. Purkar, Deepali D. Bhandari and Sunil V. Amrutkar

3.1 Introduction 108

3.2 Characteristics of Several Stem Cell Types Employed in Therapeutic Applications 110

3.3 Recent Advancements and Applications of Stem Cell Therapy 120

3.4 Current Limitations 123

3.5 Innovative Isolation and Culture Techniques and Their Use in Research on Stem Cells 125

3.6 Future Prospects 134

4 Nanobiomaterials at the Nexus: Integrating Stem Cells and Nanotechnology for Precision Therapeutics 159
Aditya Banerjee and Deepika Arora

4.1 Introduction 160

4.2 Nanobiomaterials: Tailoring the Cellular Microenvironment 163

4.3 Stem Cells for Regenerative Medicine 171

4.4 Exosomes: Natural Nanocarriers for Intercellular Communication 179

4.5 Reprogramming Immunity for Cancer Through CAR-T Cell Therapy 189

4.6 Integrating Nanobiomaterials with Stem Cells and CAR-T Cells 194

4.7 Challenges and Future Perspectives 204

4.8 Conclusion 210

4.9 Summary 215

5 Exosomes from Stem Cells as Therapeutic Agents for Cardiovascular Regeneration 227
Maryam Taghavi Narmi, Nikoo Baghal Darbandi, Abdulwahab Teflischi Gharavi, Ali Babaeizad and Mohsen Sheykhhasan

5.1 Introduction 228

5.2 Biogenesis and Characteristics of Stem-Cell-Derived Exosomes 242

5.3 Mechanism of Cardiovascular Regeneration Mediated by Exosomes 249

5.4 Therapeutic Applications of Exosomes in Cardiovascular Diseases 269

5.5 Preclinical and Clinical Studies 272

5.6 Challenges and Future Directions 277

5.7 Conclusion 279

6 Cardiovascular Renaissance: Stem Cell Strategies for Heart Diseases 309
Apurva, Pracheta Janmeda, Divya Kumari, Narotam Sharma and Priya Chaudhary

6.1 Introduction 310

6.2 Stem Cell Types Considered for the Treatment of Heart Disease 311

6.3 Stem Cell Therapy Against Different Heart Diseases 317

6.4 Mechanism of Stem-Cell Based Therapy for Heart Disease 325

6.5 Gene-Modified Stem Cells 328

6.6 Limitations of Stem Cell Strategies for Cardiovascular Diseases 331

6.7 Strategies for Improving Stem Cell Therapy 335

6.8 Bioengineering Strategies: New Era 336

6.9 Conclusion 338

7 Neurological Disorders: Advancements in Stem-Cell-Based Treatments 351
Dheeraj Sharma and Shriyansh Srivastava

7.1 Introduction 352

7.2 Types of Stem Cells 353

7.3 Mechanisms of Action 357

7.4 Technological Advancements in Stem Cell Research 358

7.5 Stem-Cell-Based Treatments for Specific Neurological Disorders 362

7.6 Clinical Trials and Case Studies 365

7.7 Ethical Considerations and Regulatory Challenges 367

7.8 Future Directions and Potential Innovations 370

7.9 Conclusion 372

8 Stem Cell Therapy for Metabolic Disorders: Harnessing the Power of Stem Cells to Treat Diabetes, Obesity, and Other Metabolic Disorders 381
Sindhu D. Bali, Anand Kumar Shukla, Rosaleen Sahoo, Varsha A. Mahadik and Narendra Kadoo

8.1 Introduction 382

8.2 Clinical Applications of Stem Cell Therapy for Metabolic Disorders 389

8.3 Molecular Mechanisms Underlying the Action of Stem Cells in Metabolic Disorders 391

8.4 Challenges and Limitations of Stem Cell Therapy for Metabolic Disorders 396

8.5 Future Directions for Stem Cell Therapy in Metabolic Disorders 399

8.6 Conclusions 401

9 Immunomodulation in Autoimmune Disorders: Harnessing the Power of Stem Cell 409
Neha Kamboj, Rahul Kumar and Debasis Mitra

9.1 Introduction 410

9.2 SCs: Types and Characteristics 412

9.3 Mechanisms of SC-Based Immunomodulation 414

9.4 Clinical Applications of SCs in Autoimmune Disorders 427

9.5 Challenges and Considerations in SC Therapy 442

9.6 Conclusion 453

10 The Microbiome Connection: Exploring Interactions with Stem Cell Therapies 463
*Rizwan Ahamad, Asad Ali, Priya Manna, N…