A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

The second edition of "Evolution in Health and Disease"(S.C. Stearns and J.C. Koella, editors) Provides a timely update that should help to further energize this interdisciplinary paradigm...[...] The coverage in "Evolution in health and disease" is broad, ranging from infectious to chronic disease and microbial genomics to life-history theory. "EVolution in health and disease"provides compelling evidence that and evolutionary perspective can lead to important and novel insights into issues relevant to human health.

Autorentext
Professor Stearns specializes in life history evolution, which links the fields of ecology and evolutionary biology, in evolutionary medicine, and in evolutionary functional genomics. He came to Yale in 2000 from the University of Basel, Switzerland, where he had been professor of zoology since 1983 and held several administrative posts. Prior to moving to Basel he was an assistant professor in the Biology Department at Reed College in Oregon. Born in Hawaii and a 1967 graduate of Yale College, Stearns earned a M.S. from the University of Wisconsin and a Ph.D. from the University of British Columbia. Professor Koella's interests lie in the coevolution of parasites and hosts. He specializes in the evolutionary epidemiology of malaria and in the application of evolutionary ideas to the control of malaria. After obtaining a Masters' in mechanical engineering at the ETH Zurich and a PhD in evolutionary biology at the University of Basel he worked for several years at the Swiss Tropical Institute Basel as a malaria epidemiologist before moving on to positions in Switzerland, Denmark and France. He arrived at Imperial College in 2005 as a Chair in Epidemiology.

Inhalt

• Preface

• Part I. Introduction

• 1: Stephen C. Stearns, Randolph M. Nesse, and David Haig: Introducing evolutionary thinking for medicine

• Part II. The history and variation of human genes

• 2: Jean-François Guégan, Franck Prugnolle, and Frédéric Thomas: Global spatial patterns of infectious diseases and human evolution

• 3: Diddahally R. Govindaraju and Lynn B. Jorde: Medically relevant variation in the human genome

• 4: Michael Bamshad and Arno G. Motulsky: Health consequences of ecogenetic variation

• 5: Kenneth K. Kidd and Judith R. Kidd: Human genetic variation of medical significance

• Part III. Natural selection and evolutionary conflicts

• 6: David Haig: Intimate relations: evolutionary conflicts of pregnancy and childhood

• 7: Richard G. Bribiescas and Peter T. Ellison: How hormones mediate tradeoffs in human health and disease

• 8: Dagan A. Loisel, Susan C. Alberts, and Carole Ober: Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk

• 9: Beverly I. Strassmann and Ruth Mace: Perspectives on human health and disease from evolutionary and behavioral ecology

• Part IV. Pathogens: resistance, virulence, variation, and emergence

• 10: Carl T. Bergstrom and Michael Feldgarden: The ecology and evolution of antibiotic resistant bacteria

• 11: Andrew F. Read and Margaret J. Mackinnon: Pathogen evolution in a vaccinated world

• 12: Dieter Ebert and James J. Bull: The evolution and expression of virulence

• 13: Paul M. Sharp, Elizabeth Bailes, and Louise V. Wain: Evolutionary origins of diversity in human viruses

• 14: Daniel Dykhuizen and Awdhesh Kalia: The population structure of pathogenic bacteria

• 15: Julian Parkhill: Whole-genome analysis of pathogen evolution

• 16: Mark Woolhouse and Rustom Antia: Emergence of new infectious diseases

• 17: Jacob C. Koella and Paul Turner: Evolution of parasites

• Part V. Noninfectious and degenerative disease

• 18: Martin Ackermann and Scott D. Pletcher: Evolutionary biology as a foundation for studying aging and aging-related disease

• 19: Christopher W. Kuzawa, Peter D. Gluckman, Mark A. Hanson, and Alan S. Beedle: Evolution, developmental plasticity, and metabolic disease

• 20: William R. Leonard: Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks

• 21: Mel Greaves: Cancer: evolutionary origins of vulnerability

• 22: Natalia L. Komarova and Dominik Wodarz: Cancer as a microevolutionary process

• 23: Steven N. Austad and Caleb E. Finch: The evolutionary context of human aging and degenerative disease

• References

• Index