Statistical Methods in Molecular Biology

This progressive book presents the basic principles of proper statistical analyses. It progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology.

While there is a wide selection of 'by experts, for experts' books in statistics and molecular biology, there is a distinct need for a book that presents the basic principles of proper statistical analyses and progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology. Statistical Methods in Molecular Biology strives to fill that gap by covering basic and intermediate statistics that are useful for classical molecular biology settings and advanced statistical techniques that can be used to help solve problems commonly encountered in modern molecular biology studies, such as supervised and unsupervised learning, hidden Markov models, methods for manipulation and analysis of high-throughput microarray and proteomic data, and methods for the synthesis of the available evidences. This detailed volume offers molecular biologists a book in a progressive style where basic statistical methods are introduced and gradually elevated to an intermediate level, while providing statisticians knowledge of various biological data generated from the field of molecular biology, the types of questions of interest to molecular biologists, and the state-of-the-art statistical approaches to analyzing the data. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work provides the kind of meticulous descriptions and implementation advice for diverse topics that are crucial for getting optimal results.

Comprehensive but convenient, Statistical Methods in Molecular Biology will aid students, scientists, and researchers along the pathway from beginning strategies to a deeper understanding of these vital systems of data analysis and interpretation within one concise volume.

"Here is a comprehensive book that systematically covers both basic and advanced statistical topics in molecularbiology, including parametric and nonparametric, and frequentist and Bayesian methods. I am highly impressed by the breadth and depth of the applications. I strongly recommend this book for both statisticians and biologists who need to communicate with each other in this exciting field of research."

• Robert C. Elston, PhD., Director, Division of Genetic and Molecular Epidemiology, Case Western Reserve University

"An extraordinary exposition of the central topics of modern molecular biology, presented by practicing experts who weave together rigorous theory with practical techniques and illustrative examples."

• George C. Newman, MD, PhD, Chairman, Neurosensory Sciences, Albert Einstein Medical Center

"I cannot think of anything we need now in translation research field more than more efficient cross talk between molecular biology and statistics. This book is just on target. It fills the gap."

• Iman Osman, MB, BCh, MD, Director, Interdisciplinary Melanoma Cooperative Program, New York University Langone Medical Center

An easily accessible reference for statistical methods in molecular miology, written by leading researchers in the field Presents a comprehensive guide to self-learning analysis tools for data generated in molecular biology studies, from basic methods to advanced, specialized methods in a progressive style Details the processing, description/visualization, and analyses of the data and software implementation Covers a wide range of statistical methods for the analyses of various types of data collected in different fields of biological sciences, including standard experimental data and high-dimensional data Includes supplementary material: sn.pub/extras

Klappentext

While there is a wide selection of 'by experts, for experts' books in statistics and molecular biology, there is a distinct need for a book that presents the basic principles of proper statistical analyses and progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology. Statistical Methods in Molecular Biology strives to fill that gap by covering basic and intermediate statistics that are useful for classical molecular biology settings and advanced statistical techniques that can be used to help solve problems commonly encountered in modern molecular biology studies, such as supervised and unsupervised learning, hidden Markov models, methods for manipulation and analysis of high-throughput microarray and proteomic data, and methods for the synthesis of the available evidences. This detailed volume offers molecular biologists a book in a progressive style where basic statistical methods are introduced and gradually elevated to an intermediate level, while providing statisticians knowledge of various biological data generated from the field of molecular biology, the types of questions of interest to molecular biologists, and the state-of-the-art statistical approaches to analyzing the data. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of meticulous descriptions and implementation advice for diverse topics that are crucial for getting optimal results.

Comprehensive but convenient, Statistical Methods in Molecular Biology will aid students, scientists, and researchers along the pathway from beginning strategies to a deeper understanding of these vital systems of data analysis and interpretation within one concise volume.

"Here is a comprehensive book that systematically covers both basic and advanced statistical topics in molecularbiology, including parametric and nonparametric, and frequentist and Bayesian methods. I am highly impressed by the breadth and depth of the applications. I strongly recommend this book for both statisticians and biologists who need to communicate with each other in this exciting field of research."

• Robert C. Elston, PhD., Director, Division of Genetic and Molecular Epidemiology, Case Western Reserve University

"An extraordinary exposition of the central topics of modern molecular biology, presented by practicing experts who weave together rigorous theory with practical techniques and illustrative examples."

• George C. Newman, MD, PhD, Chairman, Neurosensory Sciences, Albert Einstein Medical Center

"I cannot think of anything we need now in translation research field more than more efficient cross talk between molecular biology and statistics. This book is just on target. It fills the gap."

• Iman Osman, MB, BCh, MD, Director, Interdisciplinary Melanoma Cooperative Program, New York University Langone Medical Center

Inhalt
Basic Statistics.- Experimental Statistics for Biological Sciences.- Nonparametric Methods for Molecular Biology.- Basics of Bayesian Methods.- The Bayesian t-Test and Beyond.- Designs and Methods for Molecular Biology.- Sample Size and Power Calculation for Molecular Biology Studies.- Designs for Linkage Analysis and Association Studies of Complex Diseases.- to Epigenomics and Epigenome-Wide Analysis.- Exploration, Visualization, and Preprocessing of HighDimensional Data.- Statistical Methods for Microarray Data.- to the Statistical Analysis of Two-Color Microarray Data.- Building Networks with Microarray Data.- Advanced or Specialized Methods for Molecular Biology.- Support Vector Machines for Classification: A Statistical Portrait.- An Overview of Clustering Applied to Molecular Biology.- Hidden Markov Model and Its Applications in Motif Findings.- Dimension Reduction for High-Dimensional Data.- to the Development and Validation of Predictive Biomarker Models from High-Throughput Data Set…