Sphingolipid-Mediated Signal Transduction

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion. Written by leading investigators in these areas of study, this book presents a thorough, current and accessible review of how sphingolipids function to regulate these important activities.

Inhalt

1. Introduction and Overview.- 2. Ceramide: A Stress Response Mediator Involved in Growth Suppression.- 3. Ceramide and Inflammation.- 4. A Role for Ceramide in Meiosis.- 5. Ceramide, Aging and Cellular Senescence.- 6. Ceramide, a Mediator of Cytosine Arabinoside Induced Apoptosis.- 7. The Use of Cerebroside Synthase Inhibitors as Probes for Assessing the Metabolism and Function of Sphingolipids.- 8. Role of Sphingolipids in Regulating the Phospholipase D Pathway and Cell Division.- 9. Sphingosine-l-Phosphate: Member of a New Class of Lipid Second Messengers.- 10. Functional Roles of Glycosphingolipids and Sphingolipids in Signal Transduction.- 11. Ceramide Synthase and Ceramidases in the Regulation of Sphingoid Base Metabolism.- 12. Ceramidase and Signal Transduction.