The book showcases the newest research on smart nanoplatforms responding to hypoxia; an omnipresent pathological feature of many modern-day diseases and its potential applications. The book demonstrates the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings presented in chapters contributed by various experts in the field. The themes in the book touch upon critical facets to address pathological hypoxia such as nanomaterials enhancing oxygenation, hypoxia responsive nanoformulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nanoformulations to counter molecular consequences of hypoxia, and theranostics combining hypoxia detection systems with drug delivery systems. This book disseminates the current implications of smart nanomaterials in disease management that can be exploited by scholars, researchers, and pharma industries to develop, manufacture, and commercialize hypoxia targeted diagnostics and therapeutics.

Brings forth the smart nanoplatforms that can be used for diagnosing and imaging of localized hypoxic environment Disseminates the current implications of smart nanomaterials in disease management Gives a special emphasis laid on applications of hypoxia targeted smart nanoplatforms in carcinomas and tumors

Autorentext

Sachidanand Singh is a Professor in the Department of Biotechnology, Sankalchand Patel University, Visnagar, Gujarat, India is B. Tech Biotechnology, M. Tech Bioinformatics and PhD in Bioinformatics. He has postdoctoral research experience from the College of Pharmacy, Ohio State University, USA. His specialization area includes Plant Biotechnology, metagenomics, Systems Biology and Drug design. He has more than 13 years of research and academic experience. He has served for a decade in the School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamil Nadu, India. He also worked as consultant for college of pharmacy, Ohio State University as a Statistical Genetics during the year 2018. He has published more than 60 research articles in peer reviewed journals and completed one SERB, Govt of India funded project, two University research grant projects. He has received several awards in his area of research and for his teaching strategies. He has organized different conferences and workshops and received Govt. funds for the same. He has shared his area of expertise with different colleges and universities as invited speakers in different conferences and workshops. He has guided 36 B. Tech and 10 M. Tech projects. Presently 6 Ph. D students are enrolled under him and 2 Ph.D graduates are working in the field of herbal products, drug design and integrating with network biology. He has already edited around half-dozen of books for international publishing houses.

Azamal Husen served as Professor & Head, Department of Biology, University of Gondar, Ethiopia and is a Foreign Delegate at Wolaita Sodo University, Wolaita, Ethiopia. Earlier, he was a Visiting Faculty of the Forest Research Institute, and the Doon College of Agriculture and Forest at Dehra Dun, India. His research and teaching experience of 20 years involves studies of biogenic nanomaterial fabrication and application, plant responses to environmental stresses and nanomaterials at the physiological, biochemical and molecular levels, herbal medicine, and clonal propagation for improvement of tree species. He has conducted several research projects sponsored byvarious funding agencies, including the World Bank (FREEP), the National Agricultural Technology Project (NATP), the Indian Council of Agriculture Research (ICAR), the Indian Council of Forest Research Education (ICFRE); and the Japan Bank for International Cooperation (JBIC). He received four fellowships from India and a recognition award from the University of Gondar, Ethiopia, for excellent teaching, research, and community service. Husen has been on the Editorial board and the panel of reviewers of several reputed journals published by Elsevier, Frontiers Media, Taylor & Francis, Springer Nature, RSC, Oxford University Press, Sciendo, The Royal Society, CSIRO, PLOS, MDPI, John Wiley & Sons and UPM Journals. He is on the advisory board of Cambridge Scholars Publishing, UK. He is a Fellow of the Plantae group of the American Society of Plant Biologists, and a Member of the International Society of Root Research, Asian Council of Science Editors, and INPST. To his credit are over 200publications; and he is Editor-in-Chief of the American Journal of Plant Physiology. He is also working as Series Editor of 'Exploring Medicinal Plants', published by Taylor & Francis Group, USA; 'Plant Biology, Sustainability, and Climate Change', published by Elsevier, USA; and 'Smart Nanomaterials Technology', published by Springer Nature Singapore Pte Ltd. Singapore.

Klappentext

The book showcases the newest research on smart nanoplatforms responding to "hypoxia"; an omnipresent pathological feature of many modern-day diseases and its potential applications. The book demonstrates the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings presented in chapters contributed by various experts in the field. The themes in the book touch upon critical facets to address pathological hypoxia such as nanomaterials enhancing oxygenation, hypoxia responsive nanoformulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nanoformulations to counter molecular consequences of hypoxia, and theranostics combining hypoxia detection systems with drug delivery systems. This book disseminates the current implications of smart nanomaterials in disease management that can be exploited by scholars, researchers, and pharma industries to develop, manufacture, and commercialize hypoxia targeted diagnostics and therapeutics.

Inhalt
Bio-inspired nano systems interacting with the host environment: smart nano systems.- Recent progress in hypoxia-targeting: peptide-based nanomaterials.- New developments in nanotheranostics combined with intelligent bioresponsive systems.- Recent advancements in the field of stimuli-responsive nanopolymers for cancer treatment.- Novel Strategies to repress tumor hypoxia for the enhancement of cancer therapy.- Anopoxia: Antimonene-based nanoplatform for precision cancer therapy targeting cancer hypoxia.- Efficacy of diverse oxygen delivering nanoparticles in vitro and in animal models for treating hypoxia.- Anoproteomic: An approach for the identification of molecular targets associated with hypoxia.- Advances of nanomaterial with hypoxia inducible factor in periodontal inflammation.- ROS responsive silica nanoparticles for controlled and targeted drug delivery.- Tissue oxygenation and pH responsive fluorescent nano sensors in tumour diagnosis.- Hypoxia responsive nanomaterials for cerebral ischemia diagnosis.- Multifunctional hypoxia imaging nanoparticles.- Anaerobic bacteria mediated hypoxia-specific delivery of nanoparticles.- Reversible switch ON-OFF responsive nanoparticles in hypoxia management.