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For more than 50 years, Sleisenger & Fordtran’s Gastrointestinal and Liver Disease has been the definitive reference for gastroenterology and hepatology physicians, students and trainees, and the broader multi-disciplinary GI care team. Now guided by a new generation of leaders in the field, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with all aspects of GI and liver disease-everything from basic science to new techniques and technologies­­. A consistent organization, more than 1,100 full-color illustrations, and clinically practicable algorithms ensure quick access to updated and current information on the diagnosis, treatment, and management of gastrointestinal and liver diseases. The 12th edition welcomes a new senior editorial team of Drs. Raymond T. Chung, David T. Rubin, and C. Mel Wilcox, and features many improvements and additions.

• New and expanded discussions of eosinophilic disorders, MASLD (metabolic dysfunction-associated steatotic liver disease, formerly known as non-alcoholic fatty liver disease); the use of AI in endoscopy for improved detection of GI cancers; new treatments for viral hepatitis and autoimmune liver diseases; the expanded array of new treatments for inflammatory bowel disorders; and more
• New chapters on Gastrointestinal and Hepatic Manifestations of Coronavirus Infection; Enterocolitis and Hepatitis Induced by Cancer Immunotherapy, and a new section on Neoplasia Involving Multiple Organs
• Reliable coverage of a wide range of endoscopic procedures for diagnosis and treatment, including balloon dilatation, stent placement/removal, and the management of small bowel angioectasia
• Quick-reference algorithms that summarize clinical decision making and practical approaches to patient management
• A consistent, templated format throughout the text that enables quick retrieval of information, and more than 20 videos of endoscopic procedures

• An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

  Inhalt

  Part I: Biology of the Gastrointestinal Tract

  1. Cellular Growth and Neoplasia
  2. Mucosal Immunology and Inflammation
  3. The Enteric Microbiota
  4. Gut Sensory Transduction
  5. Biopsychosocial Issues in Gastroenterology

  Part II: Nutrition in Gastroenterology

  6. Nutritional Principles and the Assessment of the Gastroenterology Patient
  7. Nutritional Management
  8. Obesity
  9. Surgical and Endoscopic Treatment of Obesity
  10. Feeding and Eating Disorders
  11. Food Allergies

  Part III: Symptoms and Signs

  12. Acute Abdominal Pain
  13. Chronic Abdominal Pain
  14. Symptoms of Esophageal Disease
  15. Dyspepsia
  16. Nausea and Vomiting
  17. Diarrhea
  18. Intestinal Gas
  19. Fecal Incontinence
  20. Constipation
  21. Gastrointestinal Bleeding
  22. Jaundice
  23. Factitious Gastrointestinal Disease

  Part IV: Processes Involving Multiple Organs

  24. Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases
  25. Cutaneous Manifestations of Gastrointestinal and Liver Diseases
  26. Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine
  27. Abdominal Hernias and Gastric Volvulus
  28. Foreign Bodies, Bezoars, and Caustic Ingestions
  29. Abdominal Abscesses and Gastrointestinal Fistulas
  30. Eosinophilic Disorders of the Gastrointestinal Tract
  31. Protein-Losing Gastroenteropathy
  32. Gastrointestinal and Hepatic Manifestations of Coronavirus Infection
  33. Gastrointestinal Consequences of Infection with Human Immunodeficiency Virus
  34. Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation
  35. Gastrointestinal and Hepatic Manifestations of Systemic Diseases
  36. Vascular Lesions of the Gastrointestinal Tract
  37. Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm
  38. Gastrointestinal and Hepatic Disorders in the Pregnant Patient
  39. Acute and Chronic Gastrointestinal Side Effects of Radiation Therapy
  40. Preparation for and Complications of GI Endoscopy

  Part V: Neoplasia Involving Multiple Organs

  41. Gastrointestinal Lymphomas
  42. Gastrointestinal Stromal Tumors
  43. Neuroendocrine Tumors
  44. Enterocolitis and Hepatitis Induced by Cancer Immunotherapy

  Part VI: Esophagus

  45. Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus
  46. Esophageal Neuromuscular Function and Motility Disorders
  47. Esophageal Disorders Caused by Medications, Trauma, and Infection
  48. Gastroesophageal Reflux Disease
  49. Barrett's Esophagus
  50. Esophageal Tumors

  Part VII: Stomach and Duodenum

  51. Anatomy, Histology and Developmental Anomalies of the Stomach and Duodenum
  52. Gastric Neuromuscular Function and Neuromuscular Disorders
  53. Gastric Secretion
  54. Gastritis and Gastropathy
  55. Peptic Ulcer Disease
  56. Adenocarcinoma of the Stomach and Other Gastric Tumors

  Part VIII: Pancreas

  57. Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas
  58. Pancreatic Secretion
  59. Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood
  60. Acute Pancreatitis
  61. Chronic Pancreatitis
  62. Pancreatic Cancer, Cystic Pancreatic Neoplasms, and Other Nonendocrine Pancreatic Tumors
  63. Endoscopic Treatment of Pancreatic Disease

  Part IX: Biliary Tract

  64. Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract
  65. Biliary Tract Motor Function and Dysfunction
  66. Bile Formation and Bile Acid Cycling in Health and Disease
  67. Gallstone Disease
  68. Treatment of Gallstone Disease
  69. Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps
  70. Primary and Secondary Sclerosing Cholangitis
  71. Tumors of the Bile Ducts, Gallbladder, and Ampulla
  72. Endoscopic and Radiologic Treatment of Biliary Disease

  Part X: Liver

  73. Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver
  74. Liver Physiology and Energy Metabolism
  75. Liver Chemistry and Function Tests
  76. Overview of Cirrhosis
  77. Hemochromatosis
  78. Wilson Disease
  79. Other Inherited Metabolic Disorders of the Liver
  80. Hepatitis A
  81. Hepatitis B
  82. Hepatitis C
  83. Hepatitis D
  84. Hepatitis E
  85. Hepatitis Caused by Other Viruses
  86. Bacterial, Parasitic, and Fungal Infections of the Liver, including Liver Abscess
  87. Vascular Diseases of the Liver
  88. Alcoholic-Associated Liver Disease
  89. Metabolic dysfunction-associated steatotic liver disease/Nonalcoholic fatty liver disease
  90. Liver Disease Caused by Drugs
  91. Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements
  92. Autoimmune Hepatitis
  93. Primary Biliary Cholangitis
  94. Portal Hypertension and Variceal Bleeding
  95. Ascites and Spontaneous Bacterial Peritonitis
  96. Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease
  97. Acute Liver Failure
  98. Hepatic Tumors and Cysts
  99. Liver Transplantation

  Part XI: Small and Large Intestine

  100. Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine
  101. Small Intestinal Motor and Sensory Function and Dysfunction
  102. Colonic Motor and Sensory Function and Dysfunction
  103. Intestinal Electrolyte Absorption and Secretion
  104. Digestion and Absorption of Carbohydrate, Protein, and Fat
  105. Digestion and …