This book summarizes the potent effect of ultraviolet radiation (UVR) on the photoaging and cancer formation. Skin is the largest human organ which continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. This protection can be compromised by the aging of the skin which ultimately promotes skin inflammation, impaired wound repair, and increased risk of skin cancer. The book entails mechanistic insights into the UVR-induced immunomodulation and DNA damage in the skin to delineate the pathogenesis, and develop novel ways for prevention of photoaging of the skin cells. It also elucidates the potential of nanotechnology in the treatment of skin cancer. Further, it discusses the bioinformatics approaches to understand the molecular mechanism of photoaging and cancer formation.

The book highlights the correlation between UVR-mediated skin aging and cancer It covers the molecular mechanisms that lead to changes in the stem cell function during aging It distinctively reviews bioinformatics tools used in elucidating the molecular mechanism underlying skin aging It features various cutting-edge studies on UV-R induced melanin chemi-excitation and melanoma pathogenesis

Autorentext
Dr. Ashish Dwivedi is a Post-Doctoral Scientist in Skaggs School of Pharmacy & Pharmaceutical Sciences, Colorado University, Anschutz Medical Campus, USA. He has done his Doctoral Research from Photobiology Division, Indian Institute of Toxicology Research (IITR), Lucknow. His Doctorate research work was focused on phototoxicity assessment of different therapeutic drugs and environmental pollutants. He has eleven years of research experience in Photosciences and published numerous papers in reputed journals of Photochemistry & Photobiology, Toxicology, Biomaterials, Hazardous materials etc. Dr. Neeraj Agarwal is working as a Scientist in NCI-designated University of Colorado Comprehensive Cancer Center, Aurora, CO, USA. Previously, he has completed his Ph.D. (2001 to 2007) from Photobiology, Division of Indian Institute of Toxicology Research (IITR), Lucknow. His work was focused on determining the phototoxic potential of commonly used therapeutic drugsand their mechanism of action. He has published seven research papers and presented his work at various conferences. He has received best poster award in 2002 for the work related to ciprofloxacin phototoxicity. In 2007, he joined Louisiana Health Sciences Center (LSUHSC), New Orleans, USA as a Postdoctoral Researcher and worked for five years towards understating the role of MTBP protein in osteosarcoma metastasis and also on identifying and characterizing the cancer stem cells in osteosarcoma. He has received Scientific Excellence Award and was invited to present his work in Cancer Center Retreat in 2010. Till now, he has published 18 research articles in reputed international journals with high impact factors, including Cancer Research, Oncogene, Cell Death and Differentiation, Clinical Cancer Research, and Photochemistry and Photobiology.

Dr. Lipika Ray is a Scientist in Pharmaceutics and Pharmacokinetics division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow. She has expertise in the field of nanomedicine. Previously, she has done post-doctoral research as a DST-Young Scientist in Photobiology Division, Indian Institute of Toxicology Research (IITR), Lucknow. The project was mainly focused on phototoxicity assessment of bulk and nano-curcumin. Till now, she has fifteen years of research experience and published numerous papers in peer-reviewed journals such as Biomaterials, International Journal of Pharmaceutics, European Journal of Pharmaceutics and Biopharmaceutics, etc.

Inhalt
Chapter 1 . Skin anatomy & morphology.- Chapter 2 . Cellular & Molecular events: skin aging & cancer.- Chapter 3 . Human skin stem cell and aging.- Chapter 4 . UV-R induced skin damage: Skin againg & cancer.- Chapter 5 . UV-R induced immunomodulation :Skin aging & cancer.- Chapter 6. UV-R and Role of Pigmentation in skin aging & cancer .- Chapter 7. UV-R and Vitamin D synthesis .- Chapter 8. UV-R induced melanin chemi-excitation in melanoma pathogenesis .- Chapter 9. Future prospective of nanotechnology in skin cancer therapeutics .- Chapter 10. Role of bioinformatics in understanding of molecular mechanism and prevention of skin cancer .- Chapter 11. UV-R interaction with skin. Cases of study .- Chapter 12. Monitoring the genotoxic potential of sunlight and DNA photoprotection of sunscreen.