This book provides a comprehensive exploration of silk proteins and their conversion into advanced nanoformulations, covering a wide range of applications. It starts with an informative "Introduction to Silk Proteins and Nanoformulations," detailing their structure, properties, and sources to establish a strong basis. "Extraction and Purification of Silk Proteins" outlines crucial methods for obtaining pure silk fibroin and sericin, essential for effective utilization. "Physicochemical Properties of Silk Proteins" investigates their strong mechanical properties, thermal resistance, and biocompatibility, crucial for numerous technological advancements. Moreover, the book extensively covers how silk proteins are integrated into nanotechnology in "Nanotechnology and Silk Proteins," highlighting their crucial contribution to the development of groundbreaking nanoformulations. Detailed exploration of advanced methods for preparing silk protein nanoparticles and enhancing their surfaces is provided in "Techniques for Preparing Silk Protein Nanoparticles" and "Functionalization and Surface Modification of Silk Nanoparticles," essential for their use in drug delivery, gene therapy, and biomedical engineering. Chapters dedicated to "Biomedical Applications, "Cosmetics and Personal Care," and "Environmental Sustainability" showcase how silk nanoparticles contribute to breakthroughs in these fields, providing biodegradable, eco-friendly solutions with minimal environmental impact. The book also covers critical aspects like analytical techniques for characterization, toxicological studies, and future trends, offering a comprehensive view of silk-based nanoformulations from development to practical application. This comprehensive compilation is a crucial resource for researchers, practitioners, and students aiming to harness the potential of silk proteins, driving innovation across industries and fostering the development of sustainable, high-performance technologies and products.

Autorentext
Dr. Debnirmalya Gangopadhyay is an esteemed academic and researcher with 18 years of experience in seribiotechnology, silkworm breeding and genetics, and sericulture. His expertise also extends to the development of silk protein-based nanoconjugates for commercial applications. Dr. Gangopadhyay is currently serving as an assistant professor in the Department of Sericulture at Raiganj University, India. Throughout his career, Dr. Gangopadhyay has made significant contributions to his field, publishing over 50 articles in prestigious national and international journals. His work is well-recognized, and he has been an active member of the editorial board and a reviewer for various reputable journals. Currently, Dr. Gangopadhyay is focused on innovative research involving smart silk sericin-based nanoconjugates aimed at enhancing the shelf life of food and vegetable products, showcasing his dedication to advancing. Dr Amit Kumar Mandal, born in Kharagpur, West Bengal, India, is a distinguished academic and leading researcher in chemical biology and nano-omics. He currently heads the Centre for Nanotechnology Science (CeNS) at Raiganj University. Dr Mandal completed both his M.Sc. and PhD at the University of North Bengal and previously served as a faculty member at Vidyasagar University under the UGC-Innovative Programme. With over a decade of experience in research, teaching, and academic leadership, he has authored more than 80 peer-reviewed SCI publications, holds three research patents, and has a cumulative impact score exceeding 400, as recorded by the Web of Science. He actively contributes to the global scientific community through editorial and peer-review roles with leading publishers including Nature Portfolio, RSC, ACS, Wiley, Elsevier, and BioMed Central. A recipient of the prestigious MRSC title, Dr Mandal has earned multiple accolades, including the highly cited review published by RSC & IOP Publishing Top Cited Papers India Award (2022). He is ranked among the top 0.5% of global scholars (ScholarGPS) and among the top 3% of biological scientists in India (AD Scientific Index, 2024). His future research focuses on nano-enabled drug delivery systems, biosensors, and molecular diagnostics aimed at combating infectious diseases, and antimicrobial resistance. These projects are supported by DST-SERB and other national funding agencies. **** Prof. Ismail Ocsoy is a professor in the Faculty of Pharmacy, Erciyes University, Kayseri, Turkey. He completed his M.S. and Ph.D. inChemistry from the Department of Chemistry, University of Florida, USA. His research focuses on nano-biotechnology consisting of DNA Aptamer conjugated nanomaterial, cancer therapy models, anti-cancer, antimicrobial agents, and nano-bio-sensor for detection of antibiotic resistant bacteria. He has published more than 70 papers in highly reputable and prestigious journals. Professor Azamal Husen is a distinguished scholar with over two decades of expertise in nanobiotechnology, plant physiology, environmental botany, medicinal plants, and clonal propagation. He has held senior academic roles, including Full Professor and Head of the Department of Biology at the University of Gondar, Ethiopia, and currently serves as a Foreign Delegate at Wolaita Sodo University, Ethiopia, and Adjunct Professor at Graphic Era University, India. He has also served as a Professor at Sankalchand Patel University and Visiting Faculty at leading Indian institutions. Prof. Husen has led multiple nationally and internationally funded research projects, contributed extensively to curriculum development, trained academic professionals worldwide, delivered various lectures and has been also honored by the University of Gondar for outstanding service. Named among the World's Top 2% Scientists by Stanford University, he is a prolific author, editor, and contributor to several international journals and book series.

Inhalt

Introduction to Silk Proteins and Nanoformulations.- Extraction and Purification of Silk Proteins.- Physicochemical Properties of Silk Proteins.- Nanotechnology and Silk Proteins.- Techniques for Preparing Silk Protein Nanoparticles.- Functionalization and Surface Modification of Silk Nanoparticles.- Silk Protein-Based Nanocarriers for Drug Delivery.- Silk Nanoparticles in Gene Therapy.- Biomedical Applications of Silk Protein Nanoparticles.- Silk Protein Nanoparticles in Cosmetics and Personal Care.- Environmental and Sustainable Aspects of Silk Nanoparticles.- Silk Protein-Based Nanocomposites.- Analytical Techniques for Characterizing Silk Nanoparticles.- Toxicology and Biocompatibility of Silk Nanoparticles.- Future Perspectives and Emerging Trends of silk protein-based Nanoformulations.