Provides an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology

Emphasis is laid on the roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives

New investigators combined with more experienced investigators - as represented by the editors

Autorentext
Felix J Kim PhD , Drexel University, College of Medicine, Pharmacology and Physiology, Philadelphia, USA Gavril Pasternak MD Ph ., Memorial Sloan-Kettering Cancer Center, Anne Burnett Tandy Chair in Neurology, Molec Pharmacology and Chemistry, New York, USA

Inhalt

Preface.- Historical perspective and background - including Sigma protein subtypes and ligand selectivity.- Sigma imaging agents.- Medicinal chemistry.- 3-dimensional homology models of Sigma1.- Neuronal plasticity and ion channels.- Opioid receptors and other GPCR.- Cancer.- Neurodegenerative diseases.- Pain.- Cognition, learning, neurological disorders.- Drug abuse and addiction.- Alcohol Abuse.- Stroke and neuroprotection.