This book, now in an extensively revised second edition, provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cells of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.

Offers a comprehensive update on latest knowledge in the field Discusses stem cell replacement therapy in depth Examines the latest advances in bioengineering

Autorentext

Seunghee Cha , DDS, PhD, is a Professor of Oral & Maxillofacial Diagnostic Sciences at the University of Florida College of Dentistry. Dr. Cha is actively involved in basic and clinical science research while attending patients and serving in leadership roles for various international scientific communities. She was the former President of the Salivary Research Group of the American/International Association for Dental Research and currently oversees research and patient care as the Director of the Center for Orphaned Autoimmune Disorders. Dr. Cha's research focuses on the pathogenesis of autoimmune Sjgren's disease (SS-> SjD) and cell replacement therapy to improve dry mouth in SS ->SjD patients. In particular, she has investigated the pathological roles of anti-muscarinic type 3 receptor autoantibodies in hyposalivation, epigenetic regulation of microRNA and its functions in innate immunity, self-nucleic acid sensing mechanisms in monocytes, susceptibility genes by high-throughput genomics and proteomics, and diagnostic and therapeutic strategies for SS-> SjD. Dr. Cha has published extensively in peer-reviewed international journals.

Inhalt

Part I. Updates on Salivary Gland Development .- 1. Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues.- 2. Overview of Transcriptomic Approaches for the Study of Salivary Gland Biology and Regeneration.- 3. Mucins in Salivary Gland Development, Regeneration, and Disease with Special Emphasis on Sjögren's Disease.- Part II. Glandular Damage and Cell Replacement Therapy .- 4. Histologic Changes in the Salivary Glands Following Radiation Therapy.- 5. Adult Stem Cell Therapy for Salivary Glands, with a Special Emphasis on Mesenchymal Stem Cells: An Update.- 6. Inductive Signals for Salivary Gland Regeneration.- Part III. Bioengineering of Salivary Glands .- 7. Emerging Trends in Salivary Gland Regeneration.- 8. Matrix Biology of the Salivary Gland: A Guide for Tissue Engineering.- 9. 3D Printing Technology in Craniofacial Surgery and Salivary Gland Regeneration.- 10. Functional Salivary Gland Regeneration by Organ Replacement Therapy.- Part IV. Therapeutic Considerations for Functional Salivary Gland Restorations .- 11. Regulation of Salivary Secretion.- 12. Salivary Gland Gene Therapy in Experimental and Clinical Trials.- 13. Surgical Management of Salivary Gland Diseases.