Klappentext

Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a thorough exploration of the critical roles biomarkers play in cancer detection, diagnosis, monitoring, and therapy. Sections focus on established and emerging biomarkers like PSA and CEA, detailing their biochemical characteristics and clinical relevance, and examining metabolic pathways utilized by cancer cells, highlighting key enzymes and their therapeutic potential. The final part pf the book discusses innovative strategies targeting cell cycle checkpoints and DNA repair mechanisms, including synthetic lethality through PARP inhibitors. This essential resource provides researchers and clinicians with insights into novel metabolic targets and cutting-edge treatment strategies.

By addressing current applications and future challenges, including the integration of AI and multi-omics approaches, the book equips readers with actionable knowledge to advance personalized cancer care and navigate the dynamic landscape of oncology.

Inhalt

I. Biomarkers in Cancer Diagnosis and Treatment

1. Prostate-Specific Antigen (PSA)
2. Carcinoembryonic Antigen (CEA)
3. Tissue Polypeptide-Specific Antigen (TPS) CA72-4
4. Carbohydrate Antigen 19-9 (CA19-9)
5. Carbohydrate Antigen 125 (CA-125)
6. Carbohydrate Antigen 72-4 (CA72-4)
7. Aminopeptidase N
8. Alkaline Phosphatase
9. CD26/Dipeptidyl Peptidase (DPP)4
10. Genetic Biomarkers in Cancer
11. Immunology Biomarkers in Cancer
12. Microbiome Biomarkers in Cancer
13. Glycobiology Biomarkers in Cancer

14. Epigenetic Biomarkers in Cancer

    II. Metabolic Targets and Cancer Therapeutics

15. Introduction to Metabolic Targets and Autophagy
16. Glucose Metabolism - Hexokinase-2 (HK2), Lactate Dehydrogenase A (LDHA), Pyruvate Kinase M2 Isoform (PKM2), Pyruvate Dehydrogenase (PDK), Glucose Transporter, Enolase 1 (ENO1), and Monocarboxylate Transporter (MCT1)
17. Nucleic Acid Metabolism - Folate Cycle, Nucleotide Incorporation (DNA Polymerase/Ribonucleotide Reductase (RNR)), Deoxynucleotide Synthesis (RNR), and Thymidine Synthesis (TYMS)
18. Amino Acid Metabolism - Arginine and Asparagine, Serine/Threonine Protein Kinase (Glycogen Synthase Kinase-3 (GSK-3))
19. Glucose and Amino Acid Metabolism - Isocitrate Dehydrogenase-1 (IDH-1)

20. Glucose, Nucleic Acid, Fatty Acid, and Amino Acid Metabolism - Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

    III. Miscellaneous Cancer Therapeutic Approaches

21. Targeting DNA Repair Pathways - O-6-Methylguanine-DNA Methyltransferase (MGMT), Base Excision Repair, Double Strand Breaks Repair, and mtDNA Repair
22. Cell Cycle Inhibition - Cyclin-Dependent Kinases (CDKs), and G1 Checkpoint
23. Topoisomerase-Induced DNA Damage and Therapeutic Potential
24. Polo-like Kinase 4 (PLK4) Inhibitors in Cancer Therapy
25. Synthetic Lethality by Poly (ADP-Ribose) Polymerase Inhibitors
26. Innovative Therapeutic Approaches