This book details the scope of RNA-based biology and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. Featuring high quality illustrations, it presents a range of RNA-based mechanisms that connect in the RNA infrastructure.

RNAs form complexes with proteins and other RNAs. The RNAinfrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cellwide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNAbased biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNAbased mechanisms that connect in the RNA infrastructure.

Illustrates the scope of RNA-based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways Presents a wide range of RNA-based mechanisms that connect in the RNA infrastructure High quality illustrations

Autorentext
LESLEY J. COLLINS is a Senior Research Fellow in the Institute of Fundamental Sciences at Massey University, New Zealand. With an early background in molecular biology she now uses that knowledge in evolutionary genomics and bioinformatics. Her research interests focus on the evolution of RNA networks, especially on how they relate to the evolution of ancient eukaryotes. With the rise of new sequencing technology she was involved in the establishment of next generation sequencing at Massey University. In her spare time she is a bioinformatics consultant, a practitioner of Tai Chi, a knitter and an avid reader.

Klappentext

RNAs form complexes with proteins and other RNAs. The RNA infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA based mechanisms that connect in the RNA infrastructure.

Inhalt

The RNA Infrastructure: An Introduction to ncRNA Networks.- RNA Interactions.- Plant RNA Silencing in Viral Defence.- MicroRNAs as PostTranscriptional Machines and Their Interplay With Cellular Networks.- Spatiotemporal Aspects of MicroRNAMediated Gene Regulation.- Spliceosomal RNA Infrastructure: The Network of Splicing Components and their Regulation by miRNAs.- Construction, Structure and Dynamics of PostTranscriptional Regulatory Network Directed by RNABinding Proteins.- Safe Keeping the Message: mRNP Complexes Tweaking after Transcription.- Unexpected functions of tRNA and tRNA Processing Enzymes.- Programmed DNA Elimination in Tetrahymena : A Small RNAMediated Genome Surveillance Mechanism.- Long Noncoding RNA and Epigenomics.- PromoterAssociated Long Noncoding RNAs Repress Transcription Through a RNA Binding Protein TLS.- RNA Networks in Prokaryotes I: CRISPRs and Riboswitches.- RNA Networks in Prokaryotes II: tRNA Processing and Small RNAs.- Localization of the Bacterial RNA Infrastructure.- Small RNA Discovery and Characterisation in Eukaryotes Using HighThroughput Approaches.- How Old are RNA Networks?.