Treatment of retinoblastoma has evolved at a significant speed over the last two decades. This is the first book to focus specifically on retinoblastoma. It provides a single source for the diagnosis and care of children with this malignancy.

Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy - from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.

Information regarding the biology, treatment, and research on retinoblastoma is very scattered and has not been put together in a single book This would be the first book focused specifically on this malignancy and would have a worldwide audience Includes supplementary material: sn.pub/extras

Inhalt

Biology of Retinoblastoma.- Epidemiology.- Clinical Features, Diagnosis, Pathology.- Genetics of Retinoblastoma and Genetic Counseling.- Radiation Therapy in the Management of Retinoblastoma.- Chemotherapy in the Management of Retinoblastoma.- Treatment of Intraocular Retinoblastoma.- Treatment of Extraocular and Metastatic Retinoblastoma.- Second Malignancies and Other Long Term Effects in Retinoblastoma Survivors.- Visual Rehabilitation.- Retinoblastoma in Developing Countries.