This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker's yeast Saccharomyces cerevisiae).

An up-to-date summary of protein degradation in microorganisms (bacteria, archaea and yeast) Individual chapters by the world's leading experts in the field of regulated proteolysis Detailed mechanistic analysis of the different proteolytic machines

Inhalt

Machines of destruction - AAA+ proteases and the adaptors that control them.- The AAA+ protease Lon.- FtsH protease-mediated regulation of various cellular functions.- Regulated proteolysis in Bacillus subtilis.- Regulation of stress response pathways in Escherichia coli by proteolysis.- Regulation of the SigmaE stress response.- Pathogenic bacteria: protein degradation and virulence.- Roles of Cdc48 in regulated protein degradation in yeast.- The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis & activity control.- PUPylation and Mycobacteria.- Archea proteasomes and SAMPylation.