This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

Covers relevant concepts in stem cell biology and regenerative medicine Includes many practical elements Covers the gap between the bench and the bedside Invaluable tool for graduate and undergraduate students

Autorentext

Professor Nagwa El-Badri is the Founding Director of the Biomedical Sciences Program, and the Director of the Center of Excellence for Stem Cells and Regenerative Medicine at Zewail City of Science and Technology. She received her medical degree with honors from Cairo University College of Medicine and her Ph.D. degree with distinction from the College of Medicine, University of South Florida (USF), USA. Her postdoctoral training as a Fellow of the American Heart Association was in the field of stem cell biology. She was awarded an Initial Investigatorship Award from the American Heart Association, and received research support from the Science and Technology Development Fund, the Academy of Scientific Research and Technology, the American Heart Association, the National Institutes of Health, and several other foundations. She contributed more than 100 publications and books in the field of stem cell biology and regenerative medicine.

Prior to joining Zewail City, Dr. Nagwa El-Badri was the founder and Director of the Undergraduate and Graduate Program of Women's Health at USF. She also established the graduate program in Aging and Neuroscience, and the Medicine and Gender Scholarly Concentration at the College of Medicine, USF. At Zewail City, she established the Center of Excellence for Stem Cells and Regenerative Medicine. Her graduate students at both institutes have received numerous national and international awards, and several publications were awarded first place and gold medals in national and international conferences. She has received various awards for her research and efforts in promoting women in science. She was selected for AAMC Mid-Career Women Faculty Professional Development, USA, and received an award for Exemplary Leader in Management Position for Global Women in Stem from the Meera Kaul Foundation. She is an elected Fellow of the American College of Nutrition, and currently serves on several national and international committees, including the Arab League Education and Cultural Organization Research Committee, the Higher Education Reform Experts Committee, and the Council for Education and Scientific.

Inhalt
Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development.- Chapter 2. Embryonic and Pluripotent Stem Cells.- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis.- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes.- Chapter 5. Cancer Stem Cells and the Development of Cancer.- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus.- Chapter 7. Epigenetics in Stem Cell Biology.- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells.- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation.- Chapter 10. Tissue Engineering Modalities and Nanotechnology.- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane.- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.