This book is a comprehensive resource on the current understanding of retinoblastoma. It addresses all the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by focal treatment, intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.

Offers wide-ranging coverage of the current understanding of retinoblastoma Describes treatment approaches in detail Discusses molecular biology and genetics Includes a wealth of color and black and white images to aid understanding

Autorentext

Jasmine H. Francis , MD, is Assistant Attending in the Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York and Adjunct Attending in the Department of Ophthalmology, New York Eye and Ear Infirmary, New York. Dr. Francis gained a BA in Neuroscience, magna cum laude, from Columbia University, New York in 2002 and graduated from New York University School of Medicine in 2007. She completed an Ophthalmology Residency at the New York Eye and Ear Infirmary in 2011, having been Chief Resident for the final year and receiving the William J. & Judith Turner Outstanding Resident Award. She went on to complete an Ophthalmic Oncology Fellowship at Memorial Sloan-Kettering Cancer Center in August 2013. She is a member of the International Society of Ocular Oncology, the American Academy of Pathology and Ocular Oncology, and the American Academy of Ophthalmology. Dr. Francis has published almost 30 articles in peer-reviewed journals as lead or co-author and presented many papers at national and international conferences.

David H. Abramson , MD, has been Professor of Ophthalmology at Cornell University Medical College, New York, since 2006. He was appointed to this position after being Clinical Professor of Ophthalmology at the college since 1984. He is Chief of the Ophthalmic Oncology Service, Department of Surgery at Memorial Sloan-Kettering Cancer Center, New York, and Attending Surgeon, Department of Surgery, Ophthalmic Oncology Service and Department of Pediatrics, Memorial Hospital for Cancer and Allied Diseases, New York. Dr. Abramson has been a Fellow of the American Academy of Ophthalmology and Otolaryngology since 1975 and a Fellow of the American College of Surgeons since 1977. He is Vice-President of the Ophthalmic Laser Surgical Society and the Manhattan Ophthalmic Society. Dr. Abramson has been the recipient of many honors and awards, including an AMA Physicians RecognitionAward, the 2004 Mildred Weisenfeld Award for Excellence in Ophthalmology, a Lifetime Achievement Award from the American Academy of Ophthalmology (2008), and the Stallard Medal from Cambridge University, Cambridge, UK. In 2012 he received the John Milton McClean Medal from Weill-Cornell Medical College and the Dominick Purpura Award - Outstanding Alumnus from Albert Einstein College of Medicine. He is the lead or co-author of 500 peer-reviewed journal articles as well as many other publications.

Klappentext

This comprehensive resource on the current understanding of retinoblastoma addresses all of the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.

Inhalt

1. Molecular Biology of Retinoblastoma; 2. Challenges of Genetic Susceptibility Testing for Retinoblastom; 3. Technique of Intra-Arterial Chemotherapy for Retinoblastoma; 4. Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma; 5. Electroretinogram Monitoring of Retinoblastoma Treatment; 6. Pharmacokinetics of Chemotherapy Delivered by Ophthalmic Artery Super-Selective Infusion; 7. Drug Discovery and Repurposing for Retinoblastoma; 8. Management of High Risk Retinoblastoma; 9. Treatment of Extraocular Retinoblastoma; 10. Second Tumors in Retinoblastoma Survivors; 11. Long-Term Follow-Up of Retinoblastoma Survivors.