This book focuses on recent advances in dental gold alloys and gold nanoparticles (GNPs) for biomedical applications. Dental gold alloys combine several highly desirable mechanical properties, such as high strength, ductility, and elasticity, with extremely robust chemical stability in the mouth, known as high biocompatibility. The new edition presents advanced dental gold alloys for fixed dentures, evaluating the influence of individual elements on the mechanical and other characteristics of the alloys.

In the section on the use of GNPs as novel gold biomaterials that provide a multifunctional platform for cellular imaging, biosensing, and targeted drug delivery in tumor immunotherapy and photothermal therapy, their application for incorporation into creams and for rapid LFIA tests is demonstrated.

Starting with a comprehensive review of the development and application of dental gold alloys, the book discusses the properties of materials that are crucial for dental applications, focusing on aspects such as microstructure, mechanical properties, chemical and corrosion stability, aging, biocompatibility, and color stability. The book then focuses on the use of GNPs in dental applications, delving into various GNP synthesis techniques to specifically tailor size, shape, and stability in biological media. The new supplement presents the scientific knowledge for the use of GNPs in creams and the studies needed to evaluate their safe use. The fact is that the characterization and safety assessment of nanoparticles and other nanomaterials in cosmetics is very challenging. Cosmetic creams are complex media with multiple components that can affect the physical and chemical properties of nanomaterials, alter their behavior and complicate the transfer of their toxicological aspects to different cosmetic formulations.

In addition to these factors, it discusses how their route of exposure, surface chemistry, and how steric effects of their coating affect the biodistribution and determine the level of toxicity of GNPs in the human body. The final section presents the global manufacturers of GNPs and the characteristics of their products. This book contains reviews of the current literature and updated published experimental results and offers an attractive resource for practicing scientists and engineers working in the field of various types of gold-based biomaterials.

Autorentext

Rebeka Rudolf has been employed permanently at the University of Maribor Slovenia, Faculty of Mechanical Engineering, since 1993. In 2006 she was additionally employed by the firm Zlatarna Celje d.o.o. Slovenia as the Research Manager (Leader of the Research Group). She has focused intensively on the development of new dental alloys, studying their biocompatibility and corrosion resistance, which are the applicable values for the field of the Stomatology. Under her leadership, four Au dental alloys were patented and launched on the EU market. In the last 5 years, she has been involved actively in the field of Nanotechnology - the synthesis of the different metal nanoparticles based on the Ultrasonic Spray Pyrolysis process. In 2017, she achieved the level of Research Counsellor and Associate Professor in the University of Maribor (Habilitation field: Materials). Her bibliography consists of 1,044 units, including 172 original scientific articles. Vojkan Lazi is a Full Professor and Vice Dean at the School of Dental Medicine at the University of Belgrade. He has been employed at the University permanently since 1994. Since then he has been involved in teaching and research, especially in Dental materials in the field of New dental alloys for ceramic fused to metal restorations. He was a participant and the main researcher in six scientific projects, mainly in Dental materials. In 2008 he became a Fellow at the Advanced Prosthodontic Division at UCLA, CA - USA. He has published 52 papers, of which 45 were scientific papers, then 110 reports at international and domestic conferences and six books. So far, he has been a mentor in 6 completed Doctoral Dissertations. Peter Majeri completed his Doctoral studies in 2016 at the Institute of Materials Technology at the Faculty of Mechanical Engineering, University of Maribor. In collaboration with the Institute for Process Metallurgy and Metal Recycling, RWTH Aachen University, his research focus was on Ultrasonic Spray Pyrolysis for the production of gold nanoparticles. His activities continued on research and development projects in the field of Materials, Nanotechnology and Nanomaterials Production. Andrej Ivani is an Associate Professor at the Faculty of Civil Engineering, Transportation Engineering and Architecture at the University of Maribor. The main interests of his research include Composite materials, Biomaterials, Nanomaterials, Metal alloys, Concrete, Recycled materials and mechanical testing of various materials and structures. His bibliography consists of 328 units, including 19 scientific papers, 1 invited talk and 42 papers in conference proceedings. Gregor Kravanja is a Researcher with a Doctorate at the Faculty of Civil Engineering, Transportation and Architecture at the University of Maribor, where he is included in teaching. The main interests of his research include biomaterials fabrication using supercritical fluids, scaffolds` manufacturing, enzyme kinetics, biomaterials and mechanical testing. His bibliography consists of more than 105 units, including 22 scientific papers, 2 invited talks and 22 papers in conference proceedings. Karlo T. Rai is a Professor at the Faculty of Technology and Metallurgy, University of Belgrade, where he teaches the courses: Transport Phenomena in Materials Engineering, Surface engineering and Metallic materials in medicine; and has performed a lot of organisational functions. He has achieved more than 170 bibliographic units (peer review journals, national journals, international & national conference books and textbooks). He has participated in and coordinated numerous national and international projects.

Inhalt

Introduction.- Dental Gold Alloys.- Gold Nanoparticles.