Scintigraphic imaging with radiolabeled blood elements has continued to be a useful diagnostic modality. The major trust of recent investigation has been in simplifying labeling techniques and developing new agents that will label blood elements selectively in vitro. The VI Symposium of the International Society of Radiolabeled Blood Elements was held in Barcelona (Spain) during November 23 to 27, 1992.The conference was sponsored by the NATO Scientific Affairs Division, the USA Department of Energy and the Spanish National Health Service. This monograph comprises articles that represent most of the 85 papers (70 oral and 15 posters) presented during the symposium. The meeting was attended by 110 investigators hailed from 21 countries. Although lllIn-oxine and 99mTc-HMPAO remain the choice agents for labeling blood components for routine applications, there was heavy emphasis on developing new labeling agents that will either simplify the in vitro labeling procedure, or, even better, will label blood components selectively in vivo, by injecting the radioactive agents directly into patients. The degree of success in imaging target lesions in humans by using these agents has been excellent.

Klappentext

Proceedings of a NATO ARW held in Barcelona, Spain, November 23-27, 1992.

Zusammenfassung
Proceedings of a NATO ARW held in Barcelona, Spain, November 23-27, 1992.

Inhalt
Advances in Blood Cell Labeling: Pretargeting.- A New Direct Method of Cell-Labeling in Whole Blood by Administration of 111In Labeled Anti-Sense Oligonucleotide Probe: Evaluation of Radiolabeled Probes for Noninvasive Imaging of Inflammation and Infection.- Transchelation of 114mIn from IgG-DTPA to Abscess-Related Proteins.- The Antibody Approach of Labeling Blood Cells.- Quality Control of Radiolabelled White Cells.- Granulocyte Cell Labeling with TcN-NOET.- Arteriosclerosis and Monocyte-Adhesion In Vivo.- Stabilization of Exametazime for Leucocyte Labelling: A New Approach Using Tin Enhancement.- 99mTc Labelling of Interleukin-2 for In Vivo Targeting of Activated T-Lymphocytes.- Nitric Oxide and Prostaglandin I2 for Radiolabelling of Human Platelets.- 111In Labeling of Human IgG Using a DTPA-IgG Kit.- Quantitation of Platelet Consumption in Health and Disease.- Platelet Labeling Parameters are Influenced by Lipids and Lipoproteins.- Clinical Applications of 111In-Tropolonate Labelled Platelets.- Platelet-Emboli from Arterial Filter and Oxygenator: Major Source of Embolic Complications During Cardiopulmonary Bypass (CPB).- The Fate of Emboli Post-Recanalization of Thrombus-Occluded Artery and Vein in Yorkshire Pigs.- Direct Method of Quantitation of Platelet-Embolus and Residence Time in Brain with Radiolabeled Platelets Formed by Photodenudation of Endothelial Cells of Carotid Artery in a Rat Model.- Multicompartmental Computer Analysis of 111In-Tropolone Labelled Blood Platelet Kinetic Data in Normal Humans.- Influence of Platelet Membrane Sialic Acid and Platelet Associated IgG on Ageing and Sequestration of Blood Platelets in Baboons.- Uptake of Radiolabeled Meta-Iodobenzylguanidine by Human Platelets.- Granulocyte Kinetics.- Experiences in Immunoscintigraphy of Leukocytes.- In Vitro and In Vivo Comparison of Some Properties of Antigranulocyte Antibodies.- Antigenicity of Different Antigranulocytes Antibodies Assessed by Hama Follow-Up in Patients Undergoing Immunoscintigraphic Detection of Infections.- 111In-polyclonal IgG and 125I-LDL Accumulation in Experimental Arterial Wall Injury..- Radiation Induced Chromosomal Damage to Lymphocytes in Usual 99mTc-HMPAO Leukocyte Preparations.- Radiobiologic Study of 99mTc-HMPAO Labelled Lymphocytes.- Peptides and Proteins in Radiolabeling of Blood Elements.- >Peptides in Biomedical Sciences: Principles and Practice.- Molecular Recognition Units (MRUs) and the Imaging of Human Disease.- Techniques for Direct Radiolabeling of Monoclonal Antibodies.- Lipoprotein Labeling and Analysis Techniques.- 111In Antifibrin Monoclonal Antibodies in the Evaluation of the Deep Venous Thrombosis of the Lower Limbs: an Italian Multicenter Study.- Interactions of Blood Cells with the Vessel Wall.- Is 111In-Leucocyte Scintigraphy Useful in the Evaluation of Patients with Prolonged Fever of Unknown Origin?.- Diagnosis of Inflammatory Bone and Joint Diseases with Monoclonal Antibodies (BW 250/183).- Imaging Inflammatory Bowel Disease.- Fast Diagnosis of Abdominal Infections and Inflammatory Bowel Disease with 99mTc-HMPAO Leukocyte Scan.- 111In Labeled Lymphocyte Scintigraphy in Patients with Malignant Lymphoma.- In Vivo Detection of Lymphocytic Infiltration: Present Status and New Prospects.- Clinical Experiences with 111In Labeled Human Polyclonal IgG.- Comparison of Technetium-99m-Labelled Human Polyclonal Immunoglobulin Scintigraphy with Conventional Bone Scintigraphy in Patients with Rheumatoid Arthritis and Osteoarthritis.- Antigranulocyte Antibody Bone Marrow Scans in Cancer Patients with Metastatic Bone Superscan Appearance.- Imaging of RA Inflammed Joints with 99mTc-Labeled Specific Murine Anti-CD4-and Nonspecific Human Immunoglobulin.- 99mTc-HMPAO Radiolabeled Leucocytes in Inflammatory Bowel Disease: Spect vs Planar Scintigraphy.- First Year Evolutionary Patterns of 99mTc-HMPAO-Leukocyte Uptake in Uneventful Prosthetic Knee Joint Replacement.- Detection and Quantitative Analysis of Joint Inflammation with 99mTc-Polyclonal Human Immunoglobulin G.- Increased Lung Activity of 111In Labelled Polyclonal IgG in Patients with Aids and Active Chest Infection.- 111In-Platelets and 99mTc-Human Polyclonal Immunoglobulin (HIG) Scintigraphy in Patients with Cerebrovascular Disease.- Diagnosis of Vascular Graft Infection by 99mTc-HMPAO-Labeled Leukocyte Scan.- Labeled Platelets in Idiopathic Thrombocytopenic Purpura.- Clinical Role of Radionuclide Based Technology for Thrombus Imaging in 1992.- Clinical Applications of Radiolabeled Platelets: Kidney and Pancreas Transplantation.- 11In-Antimyosin Antibodies for Detection of Heart Transplant Rejection.- Dose-Dependent Inhibition of Acute Arterial Thrombosis by Monoclonal Antibody (16N7C2) in a Baboon Model.- HIV-Related Thrombocytopenia: Four Different Clinical Subsets.- 68Ga MPO Platelets in Human Pet Thrombus Imaging.