The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations. Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms.

Begins from the understanding that virus variation and selection in virus subpopulations are intimately related to viral disease mechanisms A central topic is the origin of the quasispecies concept Examines the implications of quasispecies dynamics for viral populations Presents and analyzes vital new research in the evolution of viral diseases Includes supplementary material: sn.pub/extras

Inhalt
What Is a Quasispecies?.- Quasispecies in Time-Dependent Environments.- Viruses as Quasispecies: Biological Implications.- Virus Fitness: Concept, Quantification, and Application to HIV Population Dynamics.- Population Bottlenecks in Quasispecies Dynamics.- Evolutionary Dynamics of HIV-1 and the Control of AIDS.- Evolution of Virulence in Picornaviruses.- Molecular Mechanisms of Poliovirus Variation and Evolution.- Hepatitis C Virus Population Dynamics During Infection.- Evolutionary Influences in Arboviral Disease.- Arenavirus Diversity and Evolution: Quasispecies In Vivo.- Mutant Clouds and Occupation of Sequence Space in Plant RNA Viruses.- Parvovirus Variation for Disease: A Difference with RNA Viruses?.- Transitions in Understanding of RNA Viruses: A Historical Perspective.