This is one of two volumes covering the latest developments in the field of purinergic and pyrimidinergic transmission, going into the roles of those signaling systems in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. HEP 151 II centers on the cardiovascular, renal, immune and endocrine systems.

This two-part volume is an update and objective state of the art of the current knowledge in the field, with particular emphasis on the development of novel therapeutic entities that may prove useful in several diseases by targeting the purinergic/pyrimidinergic system

Inhalt
Section III: Cardiovascular and Renal Systems.- 16 P1 Receptors in the Cardiovascular System.- 17 P1 and P2 Receptors in the Renal System.- 18 P2 Receptors in the Cardiovascular System.- 19 Roles of Purines and Pyrimidines in Endothelium.- 20 P1 and P2 Receptors in Platelets.- 21 Purinergic Signalling in Gut.- 22 P1 Receptors in the Respiratory System.- 23 P2 Receptors in the Respiratory System.- Section IV: Immune System.- 24 Role of P1 Receptors in Inflammation.- 25 Role of P2 Receptors in the Immune System.- 26 On the Role of the P2X7 Receptor in the Immune System.- Section V: Endocrine System.- 27 Purinergic Receptors and the Pharmacology of Type 2 Diabetes.- 28 Purinergic and Pyrimidinergic Receptor Signaling in Bone Cells.- 29 Clinical Opportunities in Purinergic Neuromodulation.