Starting with the discovery of penicillin, other antibiotics, and insulin, the quest for understanding and use of biological systems, i. e. , microorganisms and ani mal tissue, for the production of value products has lead to a dramatic increase in microbiological and bioengineering research in the last decades. Chemical and pharmaceutical companies quickly realized the huge commercial potential of these bioproducts and have spent millions of US dollars on R &D as well as on a build up of production facilities. Although there was limited knowledge about the cell's molecular mechanisms, which are the basis for the formation of the desired products, products from fermentation and extraction of biological matrices were a success right from the start. R&D projects within industry and academia on the continuous improvement of production processes, especially microbial productivity and down stream processing, allowed a fast return of investment and secured competitiveness in the market. Whereas the focus of such research projects was mainly on the discovery of strains with higher pro ductivity for the product of interest, e. g. , antibiotics, a lot of expertise and knowledge was generated allowing the use of biotechnological products and processes outside the pharmaceutical arena. The tremendous increase in knowl edge and the technological developments in microbial genetics where driven by these research projects and, accompanied with the advancements in nucleotide chemistry leading to a much better understanding of intracellular processes, served as a basis for modern molecular biology and recombinant biotech nology.

This review series covers trends in modern biotechnology All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated Electronic version available at: http://link.springer.de/series/abe/

Klappentext

The quest for the elucidation of the molecular anatomy of life has been the key driver for all the genome projects and the development of a variety of new technological areas, e.g. Genomics, Functional Genomics, Differential Display, DNA-Chips, Transcriptomics, and Proteomics. In contrast to the Genome which reflects a huge but still countable number of genes and DNA building blocks (information), the number of possible Proteomes which reflect the dynamic adaptation of protein networks in a given organism (function) to all kinds of changes is infinite. In the last decade, experimental approaches and all kinds of supporting technologies were developed which now allow scientists to address most of the problems in Proteome Analysis and Proteomics. In the present volume, the editors and authors have focused on the impact of Proteomics on products and processes, the application of Proteomics in microbiology and industrial biotechnology, as well as new important technology developments in Proteomics.

Inhalt
The Impact of Proteomics on Products and Processes.- Probing the Molecular Physiology of the Microbial Organism, Escherichia coli Using Proteomics.- A Proteomic View of Cell Physiology of Bacillus subtilis Bringing the Genome Sequence to Life.- Proteomics of Bacterial Pathogens.- Application of Proteomics to Pseudomonas aeruginosa.- Mass Spectrometry a Key Technology in Proteom Research.- Protein Arrays and Their Role in Proteomics.- Topological Proteomics, Toponomics, MELK-Technology.