The Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volumes are published online first, prior to publication in a printed book. Chapters are selected according to their importance to the understanding of biological systems, relevance to the unravelling of issues associated with health and disease, or impact on scientific or technological advances and developments.

Volume 22 presents six review chapters authored by experts in related fields. The first chapter covers carotenoid-protein interactions. Chapter two addresses the non-continuum of eukaryotic transcriptional regulation. The third chapter reviews the structure of the regulatory and catalytic domains of the photoreceptor phosphodiesterase (PDE6) holoenzyme. Chapter four reviews the current knowledge on small molecule compounds that have been evaluated as rhodopsin modulators to be considered as leads for the development of novel therapies for retinitis pigmentosa. Chapter five deals with Plasticity-associated functionality and inhibition of the HIV protease. Finally, chapter six covers single-run catalysis and kinetic control of human telomerase holoenzyme. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

Presents an overview of essential contemporary discoveries on protein molecules and diverse biological activities Provides an up-to-date review of current topics in protein science Serves as a useful guide for research scientists, clinicians, physicians, and students across broad fields of study

Autorentext

M. Zouhair Atassi is the emeritus Robert A. Welch chair of chemistry, professor of biochemistry and molecular biology, and professor of pathology and immunology at Baylor College of Medicine, Houston, Texas. Previously, he was professor of biochemistry and immunology at Mayo Medical School and Mayo Clinic, Rochester, Minnesota. He was president of the International Symposium of the Immunobiology of Proteins and the Institute of Immunology; founding editor and editor-in-chief of Critical Reviews in Immunology, Protein Journal, and Protein Reviews; and served on the editorial boards of nine other peer-reviewed journals. Professor Atassi is the editor or co-editor of 33 books; author or co-author of over 470 articles in peer-reviewed journals on protein structure, biological function, and molecular and cellular immune recognition; and has received several distinguished awards, medals, and prizes in these fields.

Inhalt

Integrated Structural Studies for Elucidating Carotenoid-Protein Interactions.- The Non-continuum Nature of Eukaryotic Transcriptional Regulation.- Photoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases.- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.- Elasticity-Associated Functionality and Inhibition of the HIV Protease.- Single-Run Catalysis and Kinetic Control of Human Telomerase Holoenzyme.